Young African American men have altered macrovascular and microvascular function. In this cross-sectional study, we tested the hypothesis that vascular dysfunction in young African American men would contribute to greater central blood pressure when compared to young white men. Fifty-five young (23 yrs) healthy men (25 African American and 30 White) underwent measures of vascular structure and function including carotid artery intima-media thickness (IMT) and carotid artery beta-stiffness via ultrasonography, aortic pulse wave velocity, aortic augmentation index (AIx) and wave reflection travel time (Tr) via radial artery tonometery and a generalized transfer function, and microvascular vasodilatory capacity of forearm resistance arteries with strain-gauge plethysmography. African American men had similar brachial systolic blood pressure (SBP) but greater aortic SBP (p<0.05) and carotid SBP (p<0.05). African American men also had greater carotid IMT, greater carotid beta-stiffness, greater aortic stiffness and AIx, reduced aortic Tr and reduced peak hyperemic and total hyperemic forearm blood flow compared with white men (p<0.05). In conclusion, young African American men have greater central BP despite comparable brachial BP when compared with young white men. Diffuse macrovascular and microvascular dysfunction manifesting as carotid hypertrophy, increased stiffness of central elastic arteries, heightened resistance artery constriction/blunted resistance artery dilation and greater arterial wave reflection is present at a young age in apparently healthy African American men and conventional brachial BP measurement does not reflect this vascular burden.