AJP - Heart AJP: Heart and Circulatory Physiology
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Am J Physiol Heart Circ Physiol 234: H432-H438, 1978;
0363-6135/78 $5.00
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AJP - Heart and Circulatory Physiology, Vol 234, Issue 4 432-H438, Copyright © 1978 by American Physiological Society

ARTICLES

Interaction of acetylcholine and epinephrine on heart cyclic AMP-dependent protein kinase

S. L. Keely Jr, T. M. Lincoln and J. D. Corbin

In the isolated perfused rat heart, epinephrine produced a rapid, concentration-dependent increase in cyclic adenosine 3',5'-monophosphate (cAMP), activation of cAMP-dependent protein kinase, activation of phosphorylase, and increase in contractile force. At epinephrine concentrations of 1 micron or less, acetylcholine antagonized all these beta-adrenergic effects and also increased cyclic guanosine 3',5'-monophosphate (cGMP) levels. When used alone, acetylcholine produced a rapid elevation of cGMP and markedly diminished contractile force but did not significantly lower basal cAMP levels or cAMP-dependent protein kinase activity. The data suggest that changes in cAMP-dependent protein kinase activity can explain the antagonism of epinephrine-induced activation of phosphorylase by acetylcholine, but cannot completely account for the inhibitory effect of the cholinergic agent on contractile force.




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