AJP - Heart and Circulatory Physiology, Vol 234, Issue 6 701-H705, Copyright © 1978 by American Physiological Society
Shear stress and aortic histamine synthesis
J. M. DeForrest and T. M. Hollis
Aortic histamine-forming capacity (HFC) has been examined in relationship
to the applied mean shear stress intensity created by pulsatile perfusion
of rabbit aortas with platelet-free blood for a 1-h period. Mean shear
stress intensities ranged from 22 to 109 dyn/cm2. Results indicate that a
high correlation exists between the shear stress and the HFC which is
described by the regression equation y = 0.28 x -6.1, where y = HFC and x =
mean shear stress intensity. Results suggest that the rate of histamine
formation is sensitive to the applied shear stress, and that the histidine
decarboxylase system of the aorta may have the potential of serving as one
coupling agent between applied hemodynamic stress and resultant alterations
in aortic wall resistance to macromolecules.
