AJP - Heart and Circulatory Physiology, Vol 244, Issue 2 201-H205, Copyright © 1983 by American Physiological Society
Hormonal and renal response to plasma volume expansion in the primate Macaca mulatta
G. E. Billman, M. J. Keyl, D. T. Dickey, D. C. Kem, L. C. Keil and H. L. Stone
The purpose of this study was to investigate the hormonal and renal
response to plasma volume expansion in the ketamine-anesthetized rhesus
monkey. The blood volume was determined in nine animals and found to be 6%
of the body weight. Six monkeys received isoncotic isotonic fluid amounting
to 25% of the blood volume. Plasma volume expansion led to significant
decrease in the plasma concentrations of antidiuretic hormone (46.7%) and
aldosterone (78.4%) as well as plasma renin activity (50.0%). The mean
arterial pressure, plasma osmolality, and plasma concentrations of Na+ and
K+ were unaffected by plasma volume expansion. However, renal plasma flow,
glomerular filtration rate, the excretion of Na+ and K+, and urine flow
increased. It was concluded that, in the ketamine-anesthetized rhesus
monkey, circulating hormones contribute to blood volume homeostasis
presumably through a neural mechanism similar to that observed in dogs and
humans.
