AJP - Heart and Circulatory Physiology, Vol 244, Issue 3 362-H369, Copyright © 1983 by American Physiological Society
Cardiopulmonary reflexes and arterial pressure during rest and exercise in dogs
S. C. Walgenbach and D. E. Donald
Mean arterial blood pressure, heart rate, and cardiac output were monitored
at rest and during exercise of two grades of severity in conscious dogs
under control conditions and after progressive interruption of the
baroreflexes. Aortic arch denervation and vascular isolation and
pressurization of the carotid sinuses were used to interrupt arterial
baroreflexes. Subsequent interruption of cardiopulmonary afferents was
produced by acute bilateral cervical vagotomy. The results indicate that 1)
with the cardiopulmonary receptors alone operative, the arterial blood
pressure response to exercise is abnormal, 2) cardiopulmonary receptors do
not contribute to the moment-to-moment modulation of arterial pressure, and
3) the carotid sinuses, aortic arch, and cardiopulmonary receptors are all
involved in determining the mean level of arterial blood pressure. It is
concluded that vagally innervated cardiopulmonary receptors do not have a
significant role in regulating arterial blood pressure during exercise but
are involved in establishing the general level of arterial blood pressure.
