AJP - Heart and Circulatory Physiology, Vol 245, Issue 6 1013-H1018, Copyright © 1983 by American Physiological Society

ARTICLES

Centrally induced cardiovascular and sympathetic responses to hydrocortisone in rats

H. Takahashi, K. Takeda, H. Ashizawa, A. Inoue, S. Yoneda, M. Yoshimura and H. Ijichi

Central effects of hydrocortisone were investigated by injecting it intracerebroventricularly (icv) while recording blood pressure and heart rate in awake rats. Dose-dependent increases in both blood pressure and heart rate occurred following injections of hydrocortisone. Pretreatment by icv injections of the angiotensin II antagonist, [Sar1-Ile8]angiotensin II, completely abolished vasopressor responses to subsequent injections of hydrocortisone. When rats were later anesthetized with urethan to allow recording of abdominal sympathetic nerve activity, hydrocortisone produced vasopressor responses accompanied by corresponding increases in sympathetic nerve firing, which were also abolished by central pretreatment with either [Sar1-Ile8]angiotensin II or angiotensin I converting-enzyme inhibitor, captopril. These results indicate that centrally administered hydrocortisone stimulates the brain renin-angiotensin system to produce vasopressor responses by increasing sympathetic nerve firing.

This article has been cited by other articles:

				D. A. Scheuer, A. G. Bechtold, and K. A. Vernon Chronic Activation of Dorsal Hindbrain Corticosteroid Receptors Augments the Arterial Pressure Response to Acute Stress Hypertension, January 1, 2007; 49(1): 127 - 133. [Abstract] [Full Text] [PDF]

				A. G. Bechtold and D. A. Scheuer Glucocorticoids act in the dorsal hindbrain to modulate baroreflex control of heart rate Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R1003 - R1011. [Abstract] [Full Text] [PDF]

				D. A. Scheuer, A. G. Bechtold, S. S. Shank, and S. F. Akana Glucocorticoids act in the dorsal hindbrain to increase arterial pressure Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H458 - H467. [Abstract] [Full Text] [PDF]

				S. S. Shank and D. A. Scheuer Glucocorticoids reduce responses to AMPA receptor activation and blockade in nucleus tractus solitarius Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1751 - H1761. [Abstract] [Full Text] [PDF]

				J. L. Segar, T. Van Natta, and O. J. Smith Effects of fetal ovine adrenalectomy on sympathetic and baroreflex responses at birth Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R460 - R467. [Abstract] [Full Text] [PDF]

				D. A. Scheuer and A. G. Bechtold Glucocorticoids modulate baroreflex control of heart rate in conscious normotensive rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2002; 282(2): R475 - R483. [Abstract] [Full Text] [PDF]

				D. A. Scheuer and A. G. Bechtold Glucocorticoids potentiate central actions of angiotensin to increase arterial pressure Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2001; 280(6): R1719 - R1726. [Abstract] [Full Text] [PDF]

				D. A. Scheuer and S. W. Mifflin Glucocorticoids modulate baroreflex control of renal sympathetic nerve activity Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1440 - R1449. [Abstract] [Full Text] [PDF]