AJP - Heart and Circulatory Physiology, Vol 245, Issue 6 942-H946, Copyright © 1983 by American Physiological Society
Effects of indomethacin in conscious dogs with experimental high-output heart failure
D. Villarreal, J. O. Davis, R. H. Freeman, J. R. Dietz and S. F. Echtenkamp
The role of renal prostaglandins in the control of renin release and renal
hemodynamic function (RHF) was studied in conscious dogs with a surgically
created infrarenal aortocaval fistula, a model of high-output heart failure
(HOHF). In series 1 during acute cardiac failure, indomethacin
administration produced striking reductions in RHF but failed to alter the
high level of plasma renin activity (PRA). In series 2, administration of
indomethacin to dogs with chronic HOHF also resulted in pronounced
decrements in RHF in spite of normal levels of PRA. Studies of individual
animals with meclofenamate in both series 1 and 2 confirmed the findings
with indomethacin with one exception; in one dog with chronic severe HOHF a
very high level of PRA was present initially and fell 44% after
meclofenamate. These observations indicate that in the acute and chronic
phases of HOHF prostaglandins are involved in the maintenance of renal
blood flow and glomerular filtration rate but do not play an essential role
in the control of renin release.
