AJP - Heart pressure measurements
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 245: H957-H961, 1983;
0363-6135/83 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (96)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mukherjee, A.
Right arrow Articles by Willerson, J. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mukherjee, A.
Right arrow Articles by Willerson, J. T.

AJP - Heart and Circulatory Physiology, Vol 245, Issue 6 957-H961, Copyright © 1983 by American Physiological Society

ARTICLES

Differences in myocardial alpha- and beta-adrenergic receptor numbers in different species

A. Mukherjee, Z. Haghani, J. Brady, L. Bush, W. McBride, L. M. Buja and J. T. Willerson

In the present study, we tested the hypotheses that 1) different species have different myocardial adrenergic receptor numbers and 2) selected "slow-channel" calcium antagonists compete with alpha-adrenergic antagonists for binding to varying degrees in different species. The data obtained in the present study demonstrate that there is a markedly decreased number of alpha 1-adrenergic and increased number of beta-adrenergic receptors in canine compared with rabbit and rat myocardium. The differences in adrenergic receptor numbers exist without major differences in alpha 1-adrenergic receptor affinity in the species studied. There was no significant difference in left ventricular or plasma catecholamine content between the rat and dog. Selected slow-channel calcium antagonists compete for alpha 1-adrenergic receptor binding in rabbit, rat, and canine myocardium. However, only in rabbit myocardium does verapamil antagonize alpha 1-adrenergic receptor binding at moderate concentrations, whereas verapamil in canine and rat myocardium and 1) 600 in all three species antagonize alpha 1-adrenergic receptor binding only at relatively high concentrations. Nifedipine, a dihydropyridine-type slow-channel calcium antagonist, had no effect on prazosin binding to rat, rabbit, and dog myocardial membranes.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
T. M. Seasholtz, G. Cai, H.-Y. Wang, and E. Friedman
Signal Transduction in Smooth Muscle: Selected Contribution: Effects of ischemia-reperfusion on vascular contractility and {alpha}1-adrenergic-receptor signaling in the rat tail artery
J Appl Physiol, August 1, 2001; 91(2): 1004 - 1010.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. H. Wang, X.-J. Du, D. J. Autelitano, C. A. Milano, and E. A. Woodcock
Adverse effects of constitutively active alpha 1B-adrenergic receptors after pressure overload in mouse hearts
Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H1079 - H1086.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online