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Am J Physiol Heart Circ Physiol 246: H129-H137, 1984;
0363-6135/84 $5.00
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AJP - Heart and Circulatory Physiology, Vol 246, Issue 1 129-H137, Copyright © 1984 by American Physiological Society

ARTICLES

Plasma pharmacokinetics and interstitial diffusion of macromolecules in a capillary bed

L. J. Nugent and R. K. Jain

Concentration-time profiles of fluorescein isothiocyanate (FITC)-conjugated bovine serum albumin and a graded series of FITC-dextrans of 20,000-70,000 molecular weight were measured within the erythrocyte-free plasma layer in individual vessels and at various positions within the interstitial tissue space of mature granulation tissue grown in a rabbit ear chamber. Sodium fluorescein was used as a representative small molecule. The plasma pharmacokinetic data were found to follow a biexponential decay in time. A one-dimensional model of diffusion adequately described interstitial transport. Interstitial diffusion coefficients decreased progressively with Stokes-Einstein radius with values for albumin being significantly reduced from that for a dextran of equivalent hydrodynamic radius. Interstitial diffusion of sodium fluorescein and albumin agreed with a fiber-matrix model, whereas the interstitial diffusion of dextrans more closely corresponded to a pore model.


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A. R. Goriely, A. L. Baldwin, and T. W. Secomb
Transient diffusion of albumin in aortic walls: effects of binding to medial elastin layers
Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2195 - H2201.
[Abstract] [Full Text] [PDF]


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