AJP - Heart and Circulatory Physiology, Vol 246, Issue 2 154-H160, Copyright © 1984 by American Physiological Society
Oxygen consumption and pressure-volume area of abnormal contractions in canine heart
H. Suga, O. Yamada, Y. Goto and Y. Igarashi
Oxygen consumption rates (VO2) of isovolumic and normally ejecting
contractions are closely correlated with their systolic pressure-volume
areas (PVA) in a stable canine left ventricle. PVA is the area in the
pressure-volume (PV) diagram that is circumscribed by the end-systolic and
end-diastolic PV relation curves and the systolic segment of the PV loop
trajectory. We studied whether VO2s of abnormally loaded ejecting
contractions were similarly correlated with their PVAs. Various abnormally
ejecting contractions were produced in the left ventricle of the
cross-circulated canine heart. VO2 and PVA data of the various abnormal
contractions and the isovolumic and normally ejecting contractions were
pooled together, to which the correlation and regression analyses were
applied. They could be fitted by a linear regression analyses were applied.
They could be fitted by a linear regression line with a high correlation
coefficient and a slight scatter in each heart. We therefore conclude that
PVA is the primary correlate of VO2, not only in the isovolumic and
normally ejecting contractions but also in various abnormally loaded
contractions in a given canine left ventricle with a stable contractile
state.
