AJP - Heart and Circulatory Physiology, Vol 246, Issue 3 448-H452, Copyright © 1984 by American Physiological Society
Baroreflex sensitivity and susceptibility to systolic hypertension induced by DOCA-salt in the Sabra rat
M. Weinstock, D. Schorer-Apelbaum and D. Ben-Ishay
Rats of the salt-resistant Sabra strain (SBN) have a more sensitive
baroreflex control of heart rate than do normotensive hypertension-prone
salt-sensitive (SBH) rats. To test the hypothesis that increased baroreflex
sensitivity confers resistance to hypertension, aortic baroreceptor
deafferentation (ABD) was performed in 7- to 10-wk-old SBN rats. This
treatment reduced the slope of the mean arterial pressure-heart period
(MAP-HP) relationship in response to infusions of increasing doses of
phenylephrine in conscious rats, from 1.92 +/- 0.21 to 0.66 +/- 0.11 ms X
mmHg-1 (P less than 0.01). The latter value did not differ significantly
from that of untreated SBH rats (0.56 +/- 0.07 ms X mmHg-1). Treatment of
uniphrectomized SBH, SBN-ABD, and sham-operated SBN rats for 3 wk with
deoxycorticosterone acetate (DOCA; 25-mg pellet) and 0.9% NaCl + 0.4% KCl
(to maintain normal serum K+ values) as drinking fluid caused increases in
systolic blood pressure from 126 +/- 3 to 147 +/- 5 mmHg and 104 +/- 6 to
130 +/- 8 mmHg in the former two groups, respectively, but no significant
change (105 +/- 3 to 110 +/- 4 mmHg) in SBN rats when measured by an
indwelling arterial catheter in the tail artery. The slopes of the MAP-HP
relationships of each of the above three groups of rats were not
significantly altered by DOCA-salt treatment. It is concluded that a
decrease in baroreflex control of the heart by ABD can render SBN rats
sensitive to DOCA-salt-induced systolic hypertension.
