| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 246, Issue 4 608-H614, Copyright © 1984 by American Physiological Society
ARTICLES |
E. L. Schiffrin, J. Gutkowska and J. Genest
The effect of angiotensin II (ANG II) and deoxycorticosterone acetate (DOCA) on the density (Bmax) and affinity (Kd) of binding sites for 125I-ANG II was investigated in a particulate fraction prepared from rat mesenteric arteriolar arcades. Rats were infused with ANG II via Alzet osmotic minipumps at a dose of 200 ng X kg-1 X min-1 intraperitoneally or 60 and 200 ng X kg-1 X min-1 intravenously for 5 days. Bmax was 127 +/- 5 fmol/mg protein, and Kd was 0.8 +/- 0.1 nM in controls and was reduced significantly after the intraperitoneal infusion (111 +/- 10 fmol/mg) or the lower intravenous dose (111 +/- 9 fmol/mg), whereas after the higher intravenous dose Bmax did not change (144 +/- 14 fmol/mg). Kd was unaffected in all groups. Plasma renin activity (PRA) was reduced, and plasma ANG II increased in a dose-dependent fashion after ANG II infusion. Plasma aldosterone concentration increased only in the group infused with ANG II at 200 ng X kg-1 X min-1 intravenously (to 33.8 +/- 8.0 ng/dl from 11.6 +/- 3.4). In rats implanted subcutaneously with silicone rubber impregnated with DOCA, Bmax for 125I-ANG II was significantly increased (to 142 +/- 4 fmol/mg), whereas rats receiving 1% NaCl in their drinking water had no change in binding capacity, although PRA was lower in both groups. DOCA infusion, when combined with the intravenous dose of ANG II that reduced Bmax, antagonized this action of ANG II. DOCA infusion into sodium-depleted rats partially corrected the down-regulation of vascular ANG II receptors independent of changes in PRA.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  T. Matsukawa and T. Miyamoto Does infusion of ANG II increase muscle sympathetic nerve activity in patients with primary aldosteronism? Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2008; 294(6): R1873 - R1879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Schiffrin Effects of Aldosterone on the Vasculature Hypertension, March 1, 2006; 47(3): 312 - 318. [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Sodhi, Y. S. Kanwar, and A. Sahai Hypoxia and high glucose upregulate AT1 receptor expression and potentiate ANG II-induced proliferation in VSM cells Am J Physiol Heart Circ Physiol, March 1, 2003; 284(3): H846 - H852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Nickenig and D. G. Harrison The AT1-Type Angiotensin Receptor in Oxidative Stress and Atherogenesis: Part II: AT1 Receptor Regulation Circulation, January 29, 2002; 105(4): 530 - 536. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ngarmukos and R. J. Grekin Nontraditional aspects of aldosterone physiology Am J Physiol Endocrinol Metab, December 1, 2001; 281(6): E1122 - E1127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ichiki, K. Takeda, T. Tokunou, Y. Funakoshi, K. Ito, N. Iino, and A. Takeshita Reactive Oxygen Species-Mediated Homologous Downregulation of Angiotensin II Type 1 Receptor mRNA by Angiotensin II Hypertension, February 1, 2001; 37(2): 535 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Strehlow, G. Nickenig, J. Roeling, S. Wassmann, O. Zolk, A. Knorr, and M. Bohm AT1 receptor regulation in salt-sensitive hypertension Am J Physiol Heart Circ Physiol, November 1, 1999; 277(5): H1701 - H1707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hatakeyama, S. Inaba, and I. Miyamori 11ß-Hydroxysteroid Dehydrogenase in Cultured Human Vascular Cells : Possible Role in the Development of Hypertension Hypertension, May 1, 1999; 33(5): 1179 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Robert, C. Heymes, J.-S. Silvestre, A. Sabri, B. Swynghedauw, and C. Delcayre Angiotensin AT1 Receptor Subtype as a Cardiac Target of Aldosterone : Role in Aldosterone-Salt–Induced Fibrosis Hypertension, April 1, 1999; 33(4): 981 - 986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Nickenig, J. Roling, K. Strehlow, P. Schnabel, and M. Bohm Insulin Induces Upregulation of Vascular AT1 Receptor Gene Expression by Posttranscriptional Mechanisms Circulation, December 1, 1998; 98(22): 2453 - 2460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Nickenig, K. Strehlow, J. Roeling, O. Zolk, A. Knorr, and M. Bohm Salt Induces Vascular AT1 Receptor Overexpression In Vitro and In Vivo Hypertension, June 1, 1998; 31(6): 1272 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Nickenig, A. Sachinidis, F. Michaelsen, M. Bohm, S. Seewald, and H. Vetter Upregulation of Vascular Angiotensin II Receptor Gene Expression by Low-Density Lipoprotein in Vascular Smooth Muscle Cells Circulation, January 21, 1997; 95(2): 473 - 478. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. E. Ullian and L. G. Walsh Corticosterone Metabolism and Effects on Angiotensin II Receptors in Vascular Smooth Muscle Circ. Res., October 1, 1995; 77(4): 702 - 709. [Abstract] [Full Text]
|
|
|
|
|
|
Q. N. Diep, M. El Mabrouk, P. Yue, and E. L. Schiffrin Effect of AT1 receptor blockade on cardiac apoptosis in angiotensin II-induced hypertension Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1635 - H1641. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
