AJP - Heart and Circulatory Physiology, Vol 246, Issue 4 635-H639, Copyright © 1984 by American Physiological Society
Regional myocardial blood flow and necrosis in primates following coronary occlusion
M. Lavallee and S. F. Vatner
The effects of acute coronary artery occlusion on regional myocardial blood
flow distribution in the remote nonischemic zone, the central ischemic
zone, and the lateral border zone of the infarct were evaluated in
conscious primates. Prior to coronary artery occlusion, blood flow was 1.51
+/- 0.11 in endocardial (Endo) and 1.36 +/- 0.11 ml X min-1g-1 in
epicardial (Epi) layers with an Endo-to-Epi ratio of 1.17 +/- 0.05.
Regional blood flow in the remote nonischemic zone increased by 28.0 +/-
4.7 and 31.7 +/- 3.6% for Endo and Epi layers, respectively, following
coronary occlusion and remained elevated during the subsequent 24 h. At the
center of infarct, Endo and Epi blood flows were depressed by 97.9 +/- 0.7
and by 97.9 +/- 0.8%, respectively, at 5 min after coronary occlusion and
remained severely depressed throughout the 24-h observation period. Blood
flow at the ischemic lateral border of the infarct was severely depressed
and similar to the flow at the center of the infarct, whereas the
nonischemic lateral border of the infarct had blood flow levels similar to
the remote, nonischemic myocardium. Microsphere loss was not a feature of
the primate infarct.
