AJP - Heart and Circulatory Physiology, Vol 248, Issue 2 179-H185, Copyright © 1985 by American Physiological Society

ARTICLES

Development of a cardiomyopathy in a model of noninsulin-dependent diabetes

S. W. Schaffer, B. H. Tan and G. L. Wilson

Wistar rats were injected with streptozotocin (SZ) at 3 days of age. This maneuver produced a marked glucose intolerance, as determined by intraperitoneal glucose tolerance tests, but plasma fasting and nonfasting glucose values remained at or near normal throughout the 12-mo study period. Hearts obtained from these glucose-intolerant rats exhibited a progressive cardiomyopathy that consisted of both contractile and metabolic abnormalities. Contractile abnormalities were characterized by reductions in aortic output, ventricular pressure, and cardiac work. Associated with these mechanical defects was a decrease in glucose utilization. These abnormalities were not ameliorated by acute exposure to insulin or changes in the work load of the heart. These results demonstrate that, in the rat, a progressive cardiomyopathy results from persistent glucose intolerance in the absence of fasting hyperglycemia. This cardiomyopathy is reminiscent of that described in human noninsulin-dependent diabetes.

This article has been cited by other articles:

				D.-F. Yeih, L.-Y. Lin, H.-I Yeh, Y.-J. Lai, F.-T. Chiang, C.-D. Tseng, S.-H. Chu, and Y.-Z. Tseng Temporal changes in cardiac force- and flow-generation capacity, loading conditions, and mechanical efficiency in streptozotocin-induced diabetic rats Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H867 - H874. [Abstract] [Full Text] [PDF]

				F. C. Howarth, M. Shafiullah, and M. A. Qureshi Heart/Cardiac Muscle: Chronic effects of type 2 diabetes mellitus on cardiac muscle contraction in the Goto-Kakizaki rat Exp Physiol, November 1, 2007; 92(6): 1029 - 1036. [Abstract] [Full Text] [PDF]