AJP - Heart and Circulatory Physiology, Vol 249, Issue 2 430-H437, Copyright © 1985 by American Physiological Society
Hemodynamic and regional circulatory alterations in dog during anaphylactic challenge
M. A. Kapin and J. L. Ferguson
Microspheres were employed to measure the cardiac output (CO), percent
distribution of CO (%CO), and blood flow (BF) to various tissues in the dog
during anaphylactic shock. Five minutes after challenge there was a 66 and
83% drop from control for mean arterial pressure and CO, respectively.
Arterial glucose and lactic acid rose 62 and 537%, respectively.
Furthermore, there was a narrowing of the systemic arteriovenous difference
for PO2 and a widening of the venoarterial difference for PCO2. Pressure
compensation toward control values began 5 min postchallenge and continued
through 180 min. Circulatory perturbations during severe hypotension (less
than mmHg) included depressed %CO and BF to the pancreas and spleen and
elevated %CO to the brain and adrenals. Cerebral and adrenal BF remained
unchanged at this period. BF to the kidneys, liver (hepatic artery), and
gastrointestinal tract dropped markedly as a function of increased
peripheral resistance and decreased CO. As cardiac performance improved,
blood flow to the pancreas, spleen, liver, diaphragm, and gastrointestinal
tissues returned toward control but was elevated to the adrenals and
decreased to the brain.
