AJP - Heart Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 249: H540-H546, 1985;
0363-6135/85 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rubin, M. J.
Right arrow Articles by Bohlen, H. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rubin, M. J.
Right arrow Articles by Bohlen, H. G.

AJP - Heart and Circulatory Physiology, Vol 249, Issue 3 540-H546, Copyright © 1985 by American Physiological Society

ARTICLES

Cerebral vascular autoregulation of blood flow and tissue PO2 in diabetic rats

M. J. Rubin and H. G. Bohlen

The effect of chronic, severe diabetes mellitus on the morphology, blood flow regulation, and tissue PO2 of the cerebral cortex was evaluated in adult rats. The arterioles of the diabetic animals were enlarged in terms of both lumen diameter and vessel wall area. Although resting blood flow in the diabetic rats was greater than in the normal rats, the autoregulation of cerebral blood flow was very good within an arterial pressure range of 40-150 mmHg, just as in normal rats. The resting tissue PO2 in diabetic rats was 14.9 +/- 0.5 (SEM) compared with 12.7 +/- 0.6 mmHg in normal animals and in both groups remained at or near the resting PO2 at arterial pressures from 40 to 150 mmHg. There was no apparent loss of arterioles on the cortex surface or change in length of individual arterioles in diabetic animals but there was a 20-30% decrease in the number of venules and no change in the length of individual venules. These data indicate that although the arteriolar morphology and number of venules change in the brain during diabetes, physiological function in terms of tissue PO2 and blood flow regulation is maintained within normal limits.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. D. Bauser-Heaton, J. Song, and H. G. Bohlen
Cerebral microvascular nNOS responds to lowered oxygen tension through a bumetanide-sensitive cotransporter and sodium-calcium exchanger
Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2166 - H2173.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. D. Bauser-Heaton and H. G. Bohlen
Cerebral microvascular dilation during hypotension and decreased oxygen tension: a role for nNOS
Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2193 - H2201.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. G. TSAI, P. C. JOHNSON, and M. INTAGLIETTA
Oxygen Gradients in the Microcirculation
Physiol Rev, July 1, 2003; 83(3): 933 - 963.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online