| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 250, Issue 3 509-H518, Copyright © 1986 by American Physiological Society
ARTICLES |
M. Hori, M. Inoue, M. Kitakaze, Y. Koretsune, K. Iwai, J. Tamai, H. Ito, A. Kitabatake, T. Sato and T. Kamada
To investigate the pathophysiology of acute embolization of small coronary vessels and the role of adenosine in this abnormality, regional coronary blood flow (CBF), coronary vascular resistance, arteriovenous O2 difference, lactate extraction ratio, and adenosine release were studied in 39 anesthetized open-chest dogs after acute coronary embolization with microspheres of three different diameters (15 +/- 1, 94 +/- 8, and 293 +/- 23 microns). In 16 dogs, the left anterior descending coronary artery was embolized by repetitive injections of 15-microns microspheres, up to 4.4 +/- 0.4 X 10(5)/g myocardium; at this point CBF, determined by the electromagnetic flowmeter at the proximal site of the artery, was reduced toward zero. Up to 37% of total embolization, resting CBF increased to 175 +/- 36% of control; thereafter it decreased almost linearly as the extent of embolization was increased. After embolization, coronary arteriovenous O2 difference was significantly (P less than 0.01) decreased with a marked release of adenosine in the coronary vein. Despite a hyperemic flow response of CBF in the embolized area, myocardial ischemia was not prevented; maximal increase in CBF after 100-microns microsphere embolization (141 +/- 11% of control CBF, n = 6) was significantly (P less than 0.05) less than that in 15-micron microsphere embolization, whereas 300-microns microsphere embolization minimally increased CBF (123 +/- 13%, P greater than 0.1; n = 5). Hyperemic flow remained unchanged for at least 3 h when adenosine was persistently released. Theophylline significantly attenuated this response. These results indicate that in embolization with microspheres less than 300 microns in diameter, hyperemic response of coronary blood flow occurs, probably due to the hyperemia of nonoccluded vessels in the adjacent area of ischemic foci to adenosine released from the ischemic myocardium.
This article has been cited by other articles:
|
|
 |
|
  G. Heusch, P. Kleinbongard, D. Bose, B. Levkau, M. Haude, R. Schulz, and R. Erbel Coronary Microembolization: From Bedside to Bench and Back to Bedside Circulation, November 3, 2009; 120(18): 1822 - 1836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Heusch and R. Schulz Neglect of the coronary circulation: some critical remarks on problems in the translation of cardioprotection Cardiovasc Res, October 1, 2009; 84(1): 11 - 14. [Full Text] [PDF]
|
|
|
|
|
|
P. Bahrmann, G. S. Werner, G. Heusch, M. Ferrari, T. C. Poerner, A. Voss, and H. R. Figulla Detection of Coronary Microembolization by Doppler Ultrasound in Patients With Stable Angina Pectoris Undergoing Elective Percutaneous Coronary Interventions Circulation, February 6, 2007; 115(5): 600 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Skyschally, P. Gres, S. Hoffmann, M. Haude, R. Erbel, R. Schulz, and G. Heusch Bidirectional Role of Tumor Necrosis Factor-{alpha} in Coronary Microembolization: Progressive Contractile Dysfunction Versus Delayed Protection Against Infarction Circ. Res., January 5, 2007; 100(1): 140 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-J. Verhoeff, M. Siebes, M. Meuwissen, B. Atasever, M. Voskuil, R. J. de Winter, K. T. Koch, J. G.P. Tijssen, J. A.E. Spaan, and J. J. Piek Influence of Percutaneous Coronary Intervention on Coronary Microvascular Resistance Index Circulation, January 4, 2005; 111(1): 76 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Skyschally, R. Schulz, P. Gres, I. Konietzka, C. Martin, M. Haude, R. Erbel, and G. Heusch Coronary microembolization does not induce acute preconditioning against infarction in pigs--the role of adenosine Cardiovasc Res, August 1, 2004; 63(2): 313 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Heusch and R Schulz Pathophysiology of coronary microembolisation Heart, September 1, 2003; 89(9): 981 - 982. [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Joyce, T. M. Phernetton, and R. R. Magness Effect of Uterine Blood Flow Occlusion on Shear Stress-Mediated Nitric Oxide Production and Endothelial Nitric Oxide Synthase Expression During Ovine Pregnancy Biol Reprod, July 1, 2002; 67(1): 320 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Herrmann, M. Haude, A. Lerman, R. Schulz, L. Volbracht, J. Ge, A. Schmermund, H. Wieneke, C. von Birgelen, H. Eggebrecht, et al. Abnormal Coronary Flow Velocity Reserve After Coronary Intervention Is Associated With Cardiac Marker Elevation Circulation, May 15, 2001; 103(19): 2339 - 2345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Matsumoto, H. Tachibana, Y. Ogasawara, and F. Kajiya New double-tracer digital radiography for analysis of spatial and temporal myocardial flow heterogeneity Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H465 - H474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Dorge, T. Neumann, M. Behrends, A. Skyschally, R. Schulz, C. Kasper, R. Erbel, and G. Heusch Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2587 - H2592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Glenny, S. L. Bernard, and W. J. Lamm Hemodynamic effects of 15-{micro}m-diameter microspheres on the rat pulmonary circulation J Appl Physiol, August 1, 2000; 89(2): 499 - 504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Grund, H. T. Sommerschild, T. Lyberg, K. A. Kirkeboen, and A. Ilebekk Microembolization in pigs: effects on coronary blood flow and myocardial ischemic tolerance Am J Physiol Heart Circ Physiol, August 1, 1999; 277(2): H533 - H542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Pearse, T. E. Dahms, and E. M. Wagner Microsphere-induced bronchial artery vasodilation: role of adenosine, prostacyclin, and nitric oxide Am J Physiol Heart Circ Physiol, March 1, 1998; 274(3): H760 - H768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kitakaze, T. Minamino, H. Funaya, K. Node, Y. Shinozaki, H. Mori, and M. Hori Vesnarinone Limits Infarct Size via Adenosine-Dependent Mechanisms in the Canine Heart Circulation, April 15, 1997; 95(8): 2108 - 2114. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Minamino, M. Kitakaze, K. Komamura, K. Node, H. Takeda, M. Inoue, M. Hori, and T. Kamada Activation of Protein Kinase C Increases Adenosine Production in the Hypoxic Canine Coronary Artery Through the Extracellular Pathway Arterioscler Thromb Vasc Biol, December 1, 1995; 15(12): 2298 - 2304. [Abstract] [Full Text]
|
|
|
|
|
|
T. Minamino, M. Kitakaze, T. Morioka, K. Node, Y. Shinozaki BE, M. Chujo, H. Mori, H. Takeda, M. Inoue, M. Hori, et al. Bidirectional Effects of Aminophylline on Myocardial Ischemia Circulation, September 1, 1995; 92(5): 1254 - 1260. [Abstract] [Full Text]
|
|
|
|
|
|
A. Skyschally, R. Schulz, R. Erbel, and G. Heusch Reduced coronary and inotropic reserves with coronary microembolization Am J Physiol Heart Circ Physiol, February 1, 2002; 282(2): H611 - H614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Thielmann, H. Dorge, C. Martin, S. Belosjorow, U. Schwanke, A. van de Sand, I. Konietzka, A. Buchert, A. Kruger, R. Schulz, et al. Myocardial Dysfunction With Coronary Microembolization: Signal Transduction Through a Sequence of Nitric Oxide, Tumor Necrosis Factor-{alpha}, and Sphingosine Circ. Res., April 19, 2002; 90(7): 807 - 813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Albertal, M. Voskuil, J.J. Piek, B. de Bruyne, G. Van Langenhove, P.I. Kay, M.A. Costa, E. Boersma, T. Beijsterveldt, J.E. Sousa, et al. Coronary Flow Velocity Reserve After Percutaneous Interventions Is Predictive of Periprocedural Outcome Circulation, April 2, 2002; 105(13): 1573 - 1578. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
