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Am J Physiol Heart Circ Physiol 250: H711-H717, 1986;
0363-6135/86 $5.00
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AJP - Heart and Circulatory Physiology, Vol 250, Issue 5 711-H717, Copyright © 1986 by American Physiological Society

ARTICLES

Endothelium-dependent and independent relaxation of aortic rings from hypertensive rats

J. Van de Voorde and I. Leusen

The relaxation effects of endothelium-dependent (acetylcholine, histamine) and endothelium-independent (nitroprusside, nitrite) relaxing substances were comparatively examined on contracted thoracic aortic rings from normotensive and experimental renal and desoxycorticosterone acetate (DOCA)-salt hypertensive Wistar rats. On the aorta preparations from hypertensive animals a highly significant depression of the maximal relaxation effect of histamine and acetylcholine was observed. This was not seen with nitroprusside and nitrite. By use of a bioassay technique it was demonstrated that the depression of the endothelium-mediated response is not due to a diminished release of endothelium-derived relaxing factor. Impaired coupling between the endothelium and the smooth muscle cells is suggested to be responsible for that depression.


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