AJP - Heart Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 253: H519-H523, 1987;
0363-6135/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Read, L. C.
Right arrow Articles by Berry, M. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Read, L. C.
Right arrow Articles by Berry, M. N.

AJP - Heart and Circulatory Physiology, Vol 253, Issue 3 519-H523, Copyright © 1987 by American Physiological Society

ARTICLES

Effects of thyroid state on respiration of perfused rat and guinea pig hearts

L. C. Read, P. G. Wallace and M. N. Berry

The effects of thyroid state on the respiration of the isolated heart were investigated using retrograde perfused rat and guinea pig hearts. In both species, hypothyroidism caused a marked depression in circulating thyroid hormone concentrations and in the respiration of the isolated, retrograde perfused heart. The effects on myocardial respiration could be attributed to changes in the contraction frequency and in the oxygen consumption per beat, with little contribution from basal respiration. Treatment of animals with thyroxine elevated plasma thyroid hormones to a similar extent in rats and guinea pigs. In the latter, thyroxine treatment was associated with substantial increases in the contraction frequency and the oxygen consumption per beat of the isolated heart. In contrast, only small changes were apparent in the retrograde perfused rat heart, observations that were confirmed in rat hearts perfused at near physiological work loads. It was concluded that rat hearts isolated from normal animals function at near maximal thyroid state, in contrast to the guinea pig heart, which requires higher circulating concentrations of thyroid hormones to attain maximal responses.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
O. M. Hyyti, X.-H. Ning, N. E. Buroker, M. Ge, and M. A. Portman
Thyroid hormone controls myocardial substrate metabolism through nuclear receptor-mediated and rapid posttranscriptional mechanisms
Am J Physiol Endocrinol Metab, February 1, 2006; 290(2): E372 - E379.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
J. Chehade, J. Kim, J. L. Pinnas, and A. D. Mooradian
Age-Related Changes in the Thyroid Hormone Effects on Malondialdehyde-Modified Proteins in the Rat Heart
Experimental Biology and Medicine, October 2, 1999; 222(1): 59 - 64.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
J. Pachucki, L. A. Burmeister, and P. R. Larsen
Thyroid Hormone Regulates Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel (HCN2) mRNA in the Rat Heart
Circ. Res., September 17, 1999; 85(6): 498 - 503.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online