AJP - Heart and Circulatory Physiology, Vol 255, Issue 4 704-H710, Copyright © 1988 by American Physiological Society
Changes in AdSNA and arterial catecholamines to coronary occlusion in cats
T. Honda and I. Ninomiya
Department of Cardiac Physiology, National Cardiovascular Center Research Institute, Osaka, Japan.
The relationship between adrenal (preganglionic) sympathetic nerve activity
(AdSNA), cardiac sympathetic nerve activity (CSNA), and arterial
catecholamines, i.e., epinephrine (Epi) and norepinephrine (NE), were
analyzed during 200 s of occlusion of left anterior descending coronary
artery in anesthetized cats. With coronary occlusion, AdSNA maximally
increased to 168 +/- 20% (mean +/- SE) of the control value at 20 s and
gradually decreased to 149 +/- 10% at 200 s. Mean CSNA (MCSNA), mean
arterial pressure, and heart rate decreased significantly because of
coronary occlusion. Arterial NE and Epi progressively increased from 0.54
+/- 0.05 and 0.29 +/- 0.03 ng/ml to 1.41 +/- 0.16 and 0.59 +/- 0.08 ng/ml
at 3 min after the onset of occlusion, respectively. The correlation
between AdSNA and arterial Epi (r = 0.71; P less than 0.01) and between
AdSNA and arterial NE (r = 0.57; P less than 0.05) were significant, but
the correlation between CSNA and arterial NE was not significant. On the
other hand, in adrenalectomized cats, the increases in arterial Epi and NE
did not appear during coronary occlusion. We concluded that, with coronary
occlusion, AdSNA increased and, in turn, caused an increase in arterial Epi
and NE.
