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Am J Physiol Heart Circ Physiol 256: H1006-H1011, 1989;
0363-6135/89 $5.00
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AJP - Heart and Circulatory Physiology, Vol 256, Issue 4 1006-H1011, Copyright © 1989 by American Physiological Society

ARTICLES

Sarcoplasmic reticulum function in skinned fibers of hypertrophied rat ventricle

S. Kimura, A. L. Bassett, K. Saida, M. Shimizu and R. J. Myerburg
Department of Medicine, University of Miami School of Medicine, Florida 33101.

This study was designed to examine the Ca2+ sensitivity of the contractile system and the ability of the sarcoplasmic reticulum (SR) to accumulate and release Ca2+ in chemically (saponin) skinned cardiac fibers obtained from normal and pressure-overloaded hypertrophied rat left ventricles. Left ventricular pressure overload was induced by partial ligation of the abdominal aorta 6-8 wk before study. Age- and weight-matched normal rats served as controls. Pressure over-load increased the left ventricular weight-to-body weight ratio by 51%. There were no differences in the Ca2+-tension relationship between normal and hypertrophied preparations at Ca2+ concentrations of 10(-7) to 10(-4) M. Caffeine-induced Ca2+ release from the maximally Ca2+ -loaded SR was also not different between the two groups at caffeine concentrations of 0.5-30 mM. However, when the relative amount of Ca2+ accumulated in the SR with 10(-6), 3 x 10(-6), or 10(-5) M Ca2+ loading solutions for various loading periods was estimated by the area under the 25 mM caffeine-induced contraction, the accumulation of Ca2+ was significantly slower in hypertrophied fibers than in normal fibers. We conclude that depressed Ca2+ accumulation by the SR plays a role in modulation of contractile performance in this model of chronic pressure overload in rats.


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