AJP - Heart Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 256: H1192-H1199, 1989;
0363-6135/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Massey, K. D.
Right arrow Articles by Burton, K. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Massey, K. D.
Right arrow Articles by Burton, K. P.

AJP - Heart and Circulatory Physiology, Vol 256, Issue 4 1192-H1199, Copyright © 1989 by American Physiological Society

ARTICLES

alpha-Tocopherol attenuates myocardial membrane-related alterations resulting from ischemia and reperfusion

K. D. Massey and K. P. Burton
Department of Physiology, University of Texas, Southwestern Medical Center, Dallas 75235-9040.

Myocardial ischemia and reperfusion have been shown to result in damage to the phospholipid components of cardiac myocyte cell membranes as indicated by the tissue accumulation of unesterified fatty acids (UFA). A portion of this damage and subsequent dysfunction may be a consequence of free radical-induced membrane lipid peroxidative events. alpha-Tocopherol, a lipophilic antioxidant, was used in this study as an agent by which the extent of ischemia and reperfusion injury might be decreased. Increasing rat myocardial tissue levels of alpha-tocopherol by 51% was found to attenuate lipid perturbations as determined by the accumulation of tissue UFA in an isolated heart model of global ischemia and reperfusion. Nontreated hearts made ischemic for 25 min with 30 min of reflow had a significantly increased total UFA level of 5,961 +/- 799 nmol/mg protein (P less than 0.05) compared with control perfused hearts containing 3,116 +/- 463 nmol UFA/mg protein and with alpha-tocopherol-treated ischemic and reperfused hearts containing 3,066 +/- 365 nmol UFA/mg protein. Contractile dysfunction, excessive accumulation of tissue calcium, and release of lactate dehydrogenase after ischemia and reperfusion were also reduced, demonstrating protective effects in alpha-tocopherol-treated hearts. Thus alpha-tocopherol proved effective in the attenuation of ischemia and reperfusion damage. These results suggest that reducing lipid alterations may prove beneficial in protecting against membrane damage subsequent to ischemia and reperfusion.


This article has been cited by other articles:


Home page
 HypertensionHome page
D. W. Wilde, K. D. Massey, G. K. Walker, A. Vollmer, and R. J. Grekin
High-Fat Diet Elevates Blood Pressure and Cerebrovascular Muscle Ca2+ Current
Hypertension, March 1, 2000; 35(3): 832 - 837.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. Westhuyzen, A. D. Cochrane, P. J. Tesar, T. Mau, D. B. Cross, M. P. Frenneaux, F. A. Khafagi, and S. J. Fleming
EFFECT OF PREOPERATIVE SUPPLEMENTATION WITH {{alpha}}-TOCOPHEROL AND ASCORBIC ACID ON MYOCARDIAL INJURY IN PATIENTS UNDERGOING CARDIAC OPERATIONS
J. Thorac. Cardiovasc. Surg., May 1, 1997; 113(5): 942 - 948.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online