AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 256: H940-H948, 1989;
0363-6135/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lund, T.
Right arrow Articles by Reed, R. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lund, T.
Right arrow Articles by Reed, R. K.

AJP - Heart and Circulatory Physiology, Vol 256, Issue 4 940-H948, Copyright © 1989 by American Physiological Society

ARTICLES

Mechanisms behind increased dermal imbibition pressure in acute burn edema

T. Lund, H. Onarheim, H. Wiig and R. K. Reed
Department of Physiology, University of Bergen, Norway.

We have measured tissue pressures in excised rat skin subjected to in vitro burn injury and investigated the mechanisms behind the increased imbibition (swelling) pressure in burned skin. Skin pieces wrapped in aluminum paper were immersed into boiling hot water for 10, 30, or 60 s. Dermal imbibition pressure was measured with micropipettes and tissue osmometry as interstitial fluid hydrostatic pressure (Pif) and/or interstitial fluid colloid osmotic pressure (COPif). COPif was also measured in interstitial fluid sampled with intradermal wicks. Control values of Pif (micropipettes) and of COPif (wick fluid) averaged -1.5 mmHg and -17.5 mmHg, respectively. An increase in imbibition pressure was seen after thermal injury. After 10 s of heat exposure, the imbibition pressure gain was mainly due to a strongly negative hydrostatic pressure (Pif mean value -33.3 mmHg). Pif became slightly positive and COPif increasingly negative after longer exposure (mean Pif 0.3 and mean COPif -133 mmHg after 60-s exposure). Collagen degradation and water solubility increased with extension of the heat exposure time. Thermal degradation of collagen seems to be the main mechanism responsible for the generation of increased imbibition pressure.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
L. E. B. Stuhr, A. Reith, S. Lepsoe, R. Myklebust, H. Wiig, and R. K. Reed
Fluid pressure in human dermal fibroblast aggregates measured with micropipettes
Am J Physiol Cell Physiol, November 1, 2003; 285(5): C1101 - C1108.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. W. Ruberti, S. D. Klyce, M. K. Smolek, and M. D. Karon
Anomalous Acute Inflammatory Response in Rabbit Corneal Stroma
Invest. Ophthalmol. Vis. Sci., August 1, 2000; 41(9): 2523 - 2530.
[Abstract] [Full Text]

Home page
 Physiol. Rev.Home page
C. C. Michel and F. E. Curry
Microvascular Permeability
Physiol Rev, July 1, 1999; 79(3): 703 - 761.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Berg, A. Kirkebo, and K. J. Heyeraas
Micropuncture measurements of interstitial fluid pressure in rat nasal mucosa during early inflammatory reactions
J Appl Physiol, August 1, 1998; 85(2): 465 - 470.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
W. W. Monafo
Initial Management of Burns
N. Engl. J. Med., November 21, 1996; 335(21): 1581 - 1586.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
J. E. Mogford, G. E. Davis, S. H. Platts, and G. A. Meininger
Vascular Smooth Muscle {alpha}vß3 Integrin Mediates Arteriolar Vasodilation in Response to RGD Peptides
Circ. Res., October 1, 1996; 79(4): 821 - 826.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online