AJP - Heart Calcium Transients and Cell-Sarcomere
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Am J Physiol Heart Circ Physiol 256: H1707-H1710, 1989;
0363-6135/89 $5.00
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AJP - Heart and Circulatory Physiology, Vol 256, Issue 6 1707-H1710, Copyright © 1989 by American Physiological Society


ARTICLES

An automatic syringe for coronary occlusion in long-term collateralization studies

W. M. Caldwell, D. P. McKown, J. A. Bleck, J. W. Hartley, T. Erdal, E. E. Barrett and D. Franklin
Dalton Research Center, University of Missouri, Columbia 65211.

A portable apparatus for performing repeated, brief coronary artery occlusions automatically in long-term chronic studies involving dogs and larger animals is described. The battery-operated, back-pack-carried device uses a motorized syringe driven by a digital-programmable timing circuit to inflate a coronary artery occluder for durations of 10 s to 3 min at intervals from 14 s to 16 h. A single battery charge produces 450 occlusions. The generated pressure is adjustable to 1,000 mmHg maximum. A separate fail-safe circuit monitors system operation to open a pressure-relief valve if occlusions exceed a preset duration.





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