AJP - Heart and Circulatory Physiology, Vol 257, Issue 1 209-H218, Copyright © 1989 by American Physiological Society

ARTICLES

Effect of circulating vasopressin on arterial pressure regulation in rats

C. M. Pawloski, N. M. Eicker, L. M. Ball, M. L. Mangiapane and G. D. Fink
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824.

It has been hypothesized that moderately increased blood levels of arginine vasopressin (AVP) contribute to the development and/or maintenance of hypertension. In this study, male Sprague-Dawley rats on a fixed 1 meq daily sodium intake received 10-day intravenous infusions of 0.2 and 2.0 ng.kg-1.min-1 AVP. The higher infusion rate was above the acute vasoconstrictor threshold for AVP administration and also produced a maximal antidiuretic effect. During chronic AVP administration, however, daily mean arterial pressure, heart rate, and body fluid composition were not changed, despite a maintained antidiuresis. To test the hypothesis that circulating AVP failed to cause hypertension as a result of sensitization of the baroreflex or a direct sympathoinhibitory effect of the peptide, additional experiments were performed in rats subjected to sinoaortic denervation (SAD) or ablation of the area postrema (APX). Infusion of AVP for 10 days into SAD or APX rats caused a sustained antidiuresis but did not change arterial pressure, heart rate, or body fluid composition. In all groups of rats, the depressor response to ganglionic blockade (20 mg/kg hexamethonium) was used to estimate the autonomic component of resting arterial pressure; no change in autonomic cardiovascular control was found using this method in any of the groups during AVP infusion. Long-term elevation of plasma AVP in rats, therefore, does not cause hypertension or significantly affect autonomic regulation of arterial pressure.

This article has been cited by other articles:

				P. M. O'Connor and A. W. Cowley Jr. Vasopressin-induced nitric oxide production in rat inner medullary collecting duct is dependent on V2 receptor activation of the phosphoinositide pathway Am J Physiol Renal Physiol, August 1, 2007; 293(2): F526 - F532. [Abstract] [Full Text] [PDF]

				K. Tachikawa, H. Yokoi, H. Nagasaki, H. Arima, T. Murase, Y. Sugimura, Y. Miura, M. Hirabayashi, and Y. Oiso Altered cardiovascular regulation in arginine vasopressin-overexpressing transgenic rat Am J Physiol Endocrinol Metab, December 1, 2003; 285(6): E1161 - E1166. [Abstract] [Full Text] [PDF]

				A. W. Cowley Jr., T. Mori, D. Mattson, and A.-P. Zou Role of renal NO production in the regulation of medullary blood flow Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1355 - R1369. [Abstract] [Full Text] [PDF]

				B. Yuan and A. W. Cowley Jr Evidence That Reduced Renal Medullary Nitric Oxide Synthase Activity of Dahl S Rats Enables Small Elevations of Arginine Vasopressin to Produce Sustained Hypertension Hypertension, February 1, 2001; 37(2): 524 - 528. [Abstract] [Full Text] [PDF]

				M. Szentivanyi Jr, F. Park, C. Y. Maeda, and A. W. Cowley Jr Nitric Oxide in the Renal Medulla Protects From Vasopressin-Induced Hypertension Hypertension, March 1, 2000; 35(3): 740 - 745. [Abstract] [Full Text] [PDF]

				A. W. Cowley Jr., M. M. Skelton, and T. M. Kurth Effects of long-term vasopressin receptor stimulation on medullary blood flow and arterial pressure Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1420 - R1424. [Abstract] [Full Text] [PDF]

				F. Park, A.-P. Zou, and A. W. Cowley Jr Arginine Vasopressin–Mediated Stimulation of Nitric Oxide Within the Rat Renal Medulla Hypertension, November 1, 1998; 32(5): 896 - 901. [Abstract] [Full Text] [PDF]

				Y. Nishida, H. Hosomi, and V. S. Bishop Long-term effects of AVP-induced neurohumoral interaction via area postrema on body fluid and blood pressure Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1997; 273(5): R1696 - R1703. [Abstract] [Full Text] [PDF]

				M. F. Callahan, P. Li, C. M. Ferrario, D. Ganten, and M. Morris Salt-Sensitive Hypertension in (mREN-2)27 Transgenic Rats Hypertension, March 1, 1996; 27(3): 573 - 577. [Abstract] [Full Text]