AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 257: H494-H501, 1989;
0363-6135/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cox, R. H.
Right arrow Articles by Tulenko, T. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cox, R. H.
Right arrow Articles by Tulenko, T. N.

AJP - Heart and Circulatory Physiology, Vol 257, Issue 2 494-H501, Copyright © 1989 by American Physiological Society

ARTICLES

Effects of aging on agonist-activated 86Rb efflux in arteries of Fischer 344 rats

R. H. Cox and T. N. Tulenko
Department of Physiology, Bockus Research Institute, Graduate Hospital, University of Pennsylvania, Philadelphia 19146.

Segments of thoracic aorta (DTA), tail artery (TA), and mesenteric artery branches (MAB) were obtained from male Fischer 344 rats at ages of 1, 2, 6, 12, 24, and 30 mo and were used to determine the effects of aging on agonist-activated 86Rb (and 42K) efflux. At all three arterial sites, basal efflux decreased during development (1-6 mo), but no further changes were observed with aging (6-30 mo). The initial efflux response to 10 microM norepinephrine (NE) in the presence of 1 microM propranolol exhibited either no change (DTA) or an increase (TA and MAB) during development (1-6 mo), but all three sites showed a large decrease during aging (6-30 mo). Changes in the steady-state response to NE paralleled changes in the basal efflux at all ages and arterial sites. The initial efflux response to 75 mM K+-physiological salt solution (PSS) for the DTA in the presence of 1 microM phentolamine and 1 microM propranolol decreased during development followed by an increase during aging, whereas for the TA and MAB, there were no significant changes with age. The steady-state efflux response to K+ decreased during development at all three sites but was increased only for the DTA during aging. The steady-state efflux response to K+ was not altered for the TA and MAB during aging. Efflux responses using 42K were qualitatively similar, but rate constants were quantitatively larger than those with 86Rb at all three arterial sites and at all ages.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 HypertensionHome page
R. H. Cox and I. M. Lozinskaya
Augmented Calcium Currents in Mesenteric Artery Branches of the Spontaneously Hypertensive Rat
Hypertension, December 1, 1995; 26(6): 1060 - 1064.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online