| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 257, Issue 2 626-H634, Copyright © 1989 by American Physiological Society
ARTICLES |
S. H. Abman and F. J. Accurso
Department of Pediatrics, University of Colorado School of Medicine, Denver 80262.
To determine the acute effects of increased pulmonary artery pressure and flow on the fetal pulmonary circulation, we studied the response of pulmonary blood flow and vascular reactivity to partial compression of the ductus arteriosus in 22 chronically prepared late-gestation fetal lambs. An inflatable occluder was placed loosely around the ductus arteriosus for compression. Partial compression of the ductus rapidly increased mean pulmonary artery pressure from 45 +/- 1 to 60 +/- 1 mmHg (mean +/- SE) and left pulmonary artery blood flow from 65 +/- 6 to 151 +/- 11 ml/min at 30 min (P less than 0.001; 12 animals). Despite keeping pulmonary artery pressure constant, pulmonary blood flow steadily declined and by 2 h was not different from base-line values. Pulmonary vascular resistance initially fell during the first 30 min of partial compression but then steadily increased and remained elevated above base-line values for at least 30 min after the release of the occluder (P less than 0.001). The decline of pulmonary vascular resistance during the first 30 min of compression was blunted after treatment with the cyclooxygenase inhibitor, meclofenamate (P less than 0.001; 6 animals). Rapid incremental ductus compressions demonstrated a decrease in the slope of the pressure-flow relationship from 3.30 +/- 0.27 (control) to 1.59 +/- 0.21 ml.min-1.mmHg-1 during the postcompression period (P less than 0.001; 12 animals). The vasodilation response to small increases of fetal PO2 was markedly blunted during the postcompression period (P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  P. Tourneux, M. Chester, T. Grover, and S. H. Abman Fasudil inhibits the myogenic response in the fetal pulmonary circulation Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1505 - H1513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Parker, G. Roe, T. R. Grover, and S. H. Abman Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L976 - L982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Polglase, M. J. Wallace, D. L. Morgan, and S. B. Hooper Increases in lung expansion alter pulmonary hemodynamics in fetal sheep J Appl Physiol, July 1, 2006; 101(1): 273 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Oishi, A. Azakie, C. Harmon, R. K. Fitzgerald, A. Grobe, J. Xu, K. Hendricks-Munoz, S. M. Black, and J. R. Fineman Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1922 - H1932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Resnik, J. Herron, M. Keck, D. Sukovich, B. Linden, and D. N. Cornfield Chronic intrauterine pulmonary hypertension selectively modifies pulmonary artery smooth muscle cell gene expression Am J Physiol Lung Cell Mol Physiol, March 1, 2006; 290(3): L426 - L433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Parker, T. R. Grover, J. P. Kinsella, J. R. Falck, and S. H. Abman Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L261 - L267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Larrue, S. Jaillard, M. Lorthioir, X. Roubliova, G. Butrous, T. Rakza, H. Warembourg, and L. Storme Pulmonary vascular effects of sildenafil on the development of chronic pulmonary hypertension in the ovine fetus Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1193 - L1200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Deruelle, T. R. Grover, L. Storme, and S. H. Abman Effects of BAY 41-2272, a soluble guanylate cyclase activator, on pulmonary vascular reactivity in the ovine fetus Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L727 - L733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Houfflin-Debarge, A. Delelis, S. Jaillard, B. Larrue, P. Deruelle, A. S. Ducloy, F. Puech, and L. Storme Effects of nociceptive stimuli on the pulmonary circulation in the ovine fetus Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R547 - R553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Jouannic, R. Roussin, A. A. Hislop, S. Lanone, J. Martinovic, J. Boczkowski, Y. Dumez, and A. T. Dinh-Xuan Systemic arteriovenous fistula leads to pulmonary artery remodeling and abnormal vasoreactivity in the fetal lamb Am J Physiol Lung Cell Mol Physiol, September 1, 2003; 285(3): L701 - L709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. Konduri, J. Ou, Y. Shi, and K. A. Pritchard Jr. Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H204 - H211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. Konduri and J. Mattei Role of oxidative phosphorylation and ATP release in mediating birth-related pulmonary vasodilation in fetal lambs Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1600 - H1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Storme, T. A. Parker, J. P. Kinsella, R. L. Rairigh, and S. H. Abman Chronic hypertension impairs flow-induced vasodilation and augments the myogenic response in fetal lung Am J Physiol Lung Cell Mol Physiol, January 1, 2002; 282(1): L56 - L66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Zenge, R. L. Rairigh, T. R. Grover, L. Storme, T. A. Parker, J. P. Kinsella, and S. H. Abman NO and prostaglandin interactions during hemodynamic stress in the fetal ovine pulmonary circulation Am J Physiol Lung Cell Mol Physiol, November 1, 2001; 281(5): L1157 - L1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jaillard, V. Houfflin-Debarge, Y. Riou, T. Rakza, S. Klosowski, P. Lequien, and L. Storme Effects of catecholamines on the pulmonary circulation in the ovine fetus Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2001; 281(2): R607 - R614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Bennett, M. W. Eldridge, D. Zaghi, S. E. Zaghi, J. M. Milstein, and B. W. Goetzman Form and function of fetal and neonatal pulmonary arterial bifurcations Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H3047 - H3057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Dunbar Ivy, T. D. le Cras, T. A. Parker, J. P. Zenge, M. Jakkula, N. E. Markham, J. P. Kinsella, and S. H. Abman Developmental changes in endothelin expression and activity in the ovine fetal lung Am J Physiol Lung Cell Mol Physiol, April 1, 2000; 278(4): L785 - L793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Rairigh, L. Storme, T. A. Parker, T. D. le Cras, N. Markham, M. Jakkula, and S. H. Abman Role of neuronal nitric oxide synthase in regulation of vascular and ductus arteriosus tone in the ovine fetus Am J Physiol Lung Cell Mol Physiol, January 1, 2000; 278(1): L105 - L110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Saqueton, R. B. Miller, V. A. Porter, C. E. Milla, and D. N. Cornfield NO causes perinatal pulmonary vasodilation through K+-channel activation and intracellular Ca2+ release Am J Physiol Lung Cell Mol Physiol, June 1, 1999; 276(6): L925 - L932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Rairigh, L. Storme, T. A. Parker, T. D. le Cras, J. P. Kinsella, M. Jakkula, and S. H. Abman Inducible NO synthase inhibition attenuates shear stress-induced pulmonary vasodilation in the ovine fetus Am J Physiol Lung Cell Mol Physiol, March 1, 1999; 276(3): L513 - L521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Storme, R. L. Rairigh, T. A. Parker, D. N. Cornfield, J. P. Kinsella, and S. H. Abman K+-channel blockade inhibits shear stress-induced pulmonary vasodilation in the ovine fetus Am J Physiol Lung Cell Mol Physiol, February 1, 1999; 276(2): L220 - L228. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. ZIEGLER, D. DUNBAR IVY, J. J. FOX, J. P. KINSELLA, W. R. CLARKE, and S. H. ABMAN Dipyridamole Potentiates Pulmonary Vasodilation Induced by Acetylcholine and Nitric Oxide in the Ovine Fetus Am. J. Respir. Crit. Care Med., April 1, 1998; 157(4): 1104 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Rasanen, D. C. Wood, S. Weiner, A. Ludomirski, and J. C. Huhta Role of the Pulmonary Circulation in the Distribution of Human Fetal Cardiac Output During the Second Half of Pregnancy Circulation, September 1, 1996; 94(5): 1068 - 1073. [Abstract] [Full Text]
|
|
|
|
|
|
B. Ovadia, J. M. Bekker, R. K. Fitzgerald, A. Kon, S. Thelitz, M. J. Johengen, K. Hendricks-Munoz, R. Gerrets, S. M. Black, and J. R. Fineman Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs Am J Physiol Heart Circ Physiol, March 1, 2002; 282(3): H862 - H871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Rairigh, T. A. Parker, D. D. Ivy, J. P. Kinsella, I-D. Fan, and S. H. Abman Role of Inducible Nitric Oxide Synthase in the Pulmonary Vascular Response to Birth-Related Stimuli in the Ovine Fetus Circ. Res., April 13, 2001; 88(7): 721 - 726. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
