AJP - Heart and Circulatory Physiology, Vol 257, Issue 3 834-H838, Copyright © 1989 by American Physiological Society
Effect of leukotriene D4 on blood flow to cerebrum and choroid plexus
W. G. Mayhan, F. M. Faraci, R. Spector and D. D. Heistad
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.
The purpose of this study was to examine effects of leukotriene D4 on blood
flow to the cerebrum and choroid plexus. Blood flow was measured with
microspheres in anesthetized rabbits. Under control conditions, blood flow
to the cerebrum was 37 +/- 4 ml. min-1.100 g-1 (mean +/- SE) and blood flow
to the choroid plexus was 428 +/- 52 ml.min-1.100 g-1. Intra-atrial
infusion of leukotriene D4 at 0.1 and 1.0 microgram.kg-1.min-1 did not
alter blood flow to the brain or choroid plexus, but produced a 49 +/- 3%
and 69 +/- 5% decrease in blood flow to the bowel. We also examined effects
of intracerebroventricular administration of leukotriene D4.
Intraventricular injection of 1.0 microgram of leukotriene D4 did not
affect blood flow to the cerebrum or choroid plexus. In contrast,
intraventricular injection of 1.0 microgram of angiotensin II produced a 42
+/- 4% decrease in blood flow to the choroid plexus. In summary, neither
intravascular nor intraventricular administration of leukotriene D4 affects
blood flow to the brain or choroid plexus.
