AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 257: H904-H911, 1989;
0363-6135/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ramanadham, S.
Right arrow Articles by McNeill, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ramanadham, S.
Right arrow Articles by McNeill, J. H.

AJP - Heart and Circulatory Physiology, Vol 257, Issue 3 904-H911, Copyright © 1989 by American Physiological Society

ARTICLES

Oral vanadyl sulfate in treatment of diabetes mellitus in rats

S. Ramanadham, J. J. Mongold, R. W. Brownsey, G. H. Cros and J. H. McNeill
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.

Recent reports have suggested that vanadium in the form of vanadyl (+IV) possesses insulin-like activity. Therefore, in the present study we examined the effects of administering oral vanadyl to diabetic animals. Wistar rats made diabetic with streptozotocin and age-matched controls were maintained for 10 wk in the absence and presence of vanadyl sulfate trihydrate in the drinking water. In the presence of vanadyl, decreases in rate of growth and circulating levels of insulin were the only significant alterations recorded in control animals. In contrast, diabetic animals treated with vanadyl, despite having lower body weights and insulin levels, had normal plasma concentrations of glucose, lipid, creatinine, and thyroid hormone. In addition, abnormalities in isolated working heart function and glycerol output from adipose tissue of diabetic animals were also corrected after vanadyl treatment. These results suggest that vanadium when used in the vanadyl form is effective in diminishing the diabetic state in the rat by substituting for and replacing insulin or possibly by enhancing the effects of endogenous insulin.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. Takeda, S. Mochizuki, H. K. Saini, V. Elimban, and N. S. Dhalla
Modification of alterations in cardiac function and sarcoplasmic reticulum by vanadate in ischemic-reperfused rat hearts
J Appl Physiol, September 1, 2005; 99(3): 999 - 1005.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
S. Verma, M. C. Cam, and J. H. McNeill
Nutritional Factors that Can Favorably Influence the Glucose/Insulin System: Vanadium
J. Am. Coll. Nutr., February 1, 1998; 17(1): 11 - 18.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online