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AJP - Heart and Circulatory Physiology, Vol 258, Issue 3 887-H895, Copyright © 1990 by American Physiological Society
ARTICLES |
M. Sugimachi, T. Imaizumi, K. Sunagawa, Y. Hirooka, K. Todaka, A. Takeshita and M. Nakamura
Research Institute of Angiocardiology and Cardiovascular Clinic, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
We identified, in 17 alpha-chloralose-anesthetized rabbits, the dynamic transduction characteristics of the aortic arch baroreceptors using a "white-noise technique." We recorded aortic pressure and aortic depressor nerve activity while perturbing pressure by rapid, intermittent ventricular pacing (400 beats/min). Dividing the cross-power spectrum between nerve activity and pressure by the power spectrum of pressure yielded the transfer function. The gain of the transfer function increased threefold as the frequency increased from 0.005 to 5 Hz, suggesting that the baroreceptors responded primarily to dynamic rather than to static changes in pressure. To quantify the nonlinear properties of baroreceptor transduction, we compared measured instantaneous nerve activity with that linearly predicted. We demonstrated that the major nonlinearity was attributable to "threshold". The overall baroreceptor transduction properties could be represented by a cascade connection of a linear subsystem followed by a nonlinear subsystem with threshold. The white-noise technique made it possible to identify the unbiased linear properties in a nonlinear system, and thus was very useful in identifying complex biological systems.
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T. Kawada, T. Shishido, M. Inagaki, T. Tatewaki, C. Zheng, Y. Yanagiya, M. Sugimachi, and K. Sunagawa Differential dynamic baroreflex regulation of cardiac and renal sympathetic nerve activities Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1581 - H1590. [Abstract] [Full Text] [PDF]
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T. Kawada, T. Sato, T. Shishido, M. Inagaki, T. Tatewaki, Y. Yanagiya, M. Sugimachi, and K. Sunagawa Summation of dynamic transfer characteristics of left and right carotid sinus baroreflexes in rabbits Am J Physiol Heart Circ Physiol, September 1, 1999; 277(3): H857 - H865. [Abstract] [Full Text] [PDF]
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T. Nakahara, T. Kawada, M. Sugimachi, H. Miyano, T. Sato, T. Shishido, R. Yoshimura, H. Miyashita, and K. Sunagawa Cholinesterase affects dynamic transduction properties from vagal stimulation to heart rate Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R541 - R547. [Abstract] [Full Text] [PDF]
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H. Miyano, Y. Nakayama, T. Shishido, M. Inagaki, T. Kawada, T. Sato, H. Miyashita, M. Sugimachi, J. Alexander Jr., and K. Sunagawa Dynamic sympathetic regulation of left ventricular contractility studied in the isolated canine heart Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H400 - H408. [Abstract] [Full Text] [PDF]
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T. Nakahara, T. Kawada, M. Sugimachi, H. Miyano, T. Sato, T. Shishido, R. Yoshimura, H. Miyashita, M. Inagaki, J. Alexander Jr., et al. Accumulation of cAMP augments dynamic vagal control of heart rate Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H562 - H567. [Abstract] [Full Text] [PDF]
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T. Kawada, C. Zheng, Y. Yanagiya, K. Uemura, T. Miyamoto, M. Inagaki, T. Shishido, M. Sugimachi, and K. Sunagawa High-cut characteristics of the baroreflex neural arc preserve baroreflex gain against pulsatile pressure Am J Physiol Heart Circ Physiol, March 1, 2002; 282(3): H1149 - H1156. [Abstract] [Full Text] [PDF]
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