AJP - Heart Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 260: H953-H956, 1991;
0363-6135/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ikeda, U.
Right arrow Articles by Yaginuma, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ikeda, U.
Right arrow Articles by Yaginuma, T.

AJP - Heart and Circulatory Physiology, Vol 260, Issue 3 953-H956, Copyright © 1991 by American Physiological Society

ARTICLES

Alpha 1-adrenergic stimulation is coupled to cardiac myocyte hypertrophy

U. Ikeda, Y. Tsuruya and T. Yaginuma
Department of Cardiology, Jichi Medical School, Tochigi, Japan.

We have investigated whether alpha 1-adrenergic stimulation is coupled to myocardial hypertrophy in adult rat ventricular cells (ARVC) in culture. Exposure of ARVC to norepinephrine (NE) caused a significant increase in [3H]-leucine incorporation and total protein content in ARVC. Prazosin totally inhibited the NE-stimulated leucine uptake by ARVC. Inhibition of spontaneous contraction of ARVC with KCl or verapamil did not prevent the stimulation of hypertrophy by NE. Protooncogene c-myc expression in ARVC was induced at 1 h after exposure to NE. Above results support the premise that activation of the alpha 1-adrenergic receptors by NE induces hypertrophy of ARVC, independent of changes in contractile activity.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
C. McWhinney, D. Wenham, S. Kanwal, V. Kalman, C. Hansen, and J. D. Robishaw
Constitutively Active Mutants of the alpha 1a- and the alpha 1b-Adrenergic Receptor Subtypes Reveal Coupling to Different Signaling Pathways and Physiological Responses in Rat Cardiac Myocytes
J. Biol. Chem., January 21, 2000; 275(3): 2087 - 2097.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
O.-E. Brodde and M. C. Michel
Adrenergic and Muscarinic Receptors in the Human Heart
Pharmacol. Rev., December 1, 1999; 51(4): 651 - 690.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
K.-D. SCHLUTER and H. M. PIPER
Regulation of growth in the adult cardiomyocytes
FASEB J, May 1, 1999; 13(9001): 17 - 22.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online