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Am J Physiol Heart Circ Physiol 260: H1635-H1639, 1991;
0363-6135/91 $5.00
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AJP - Heart and Circulatory Physiology, Vol 260, Issue 5 1635-H1639, Copyright © 1991 by American Physiological Society

ARTICLES

Adenosine attenuation of catecholamine-enhanced contractility of rat heart in vivo

F. D. Romano, T. S. Naimi and J. G. Dobson Jr
Department of Physiology, University of Massachusetts Medical School, Worcester 01655.

The antiadrenergic action of adenosine was examined in open- and closed-chest preparations of anesthetized rats. The positive inotropic effects of a jugular vein infusion of either isoproterenol or epinephrine were attenuated by phenylisopropyladenosine, an adenosine A1-receptor agonist. 1,3-Dipropyl,8-cyclopentylxanthine, a specific A1-receptor antagonist, inhibited the action of phenylisopropyladenosine. The results indicate that adenosine receptor-mediated mechanisms are functional in the blood-perfused rodent heart and support the possibility of a physiological role for adenosine in modulating cardiac contractility.


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