AJP - Heart Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 261: H892-H900, 1991;
0363-6135/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schwartz, G. G.
Right arrow Articles by Weiner, M. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schwartz, G. G.
Right arrow Articles by Weiner, M. W.

AJP - Heart and Circulatory Physiology, Vol 261, Issue 3 892-H900, Copyright © 1991 by American Physiological Society

ARTICLES

Metabolic and functional consequences of blunted myocardial reactive hyperemia

G. G. Schwartz, S. Schaefer, S. D. Trocha, S. Steinman, J. Gober, J. Garcia, B. Massie and M. W. Weiner
Cardiology Section, Veterans Affairs Medical Center, San Francisco, California 94121.

This study determined whether the rapidity of myocardial metabolic and contractile recovery after brief coronary occlusion depends upon the intensity of reactive hyperemia. We also tested the hypothesis that coronary flow rate modulates contractility after brief myocardial ischemia, independent of changes in phosphorus metabolites. Eight open-chest pigs were studied with phosphorus-31 nuclear magnetic resonance (NMR) spectroscopy with 14 s time resolution. After a 29-s anterior descending coronary occlusion, peak Doppler coronary flow velocity was alternately unrestricted (normal hyperemia, 443 +/- 40% of control) or limited to 159 +/- 9% of control. During 29 s coronary occlusion, phosphocreatine-to-inorganic phosphate ratio (PCr/Pi) and systolic segment shortening in the ischemic region fell to 28 +/- 4 and 7 +/- 7% of control, respectively. With normal hyperemia, PCr/Pi and segment shortening recovered within 29 s. With blunted hyperemia, recovery of both parameters was delayed an additional 29-43 s, associated with reduced subendocardial blood flow (measured with radioactive microspheres) and persistent intracellular acidosis. However, the relationship between segment shortening and PCr/Pi was unaffected by the intensity of reactive hyperemia. Thus blunted reactive hyperemia significantly delays metabolic and contractile recovery from brief ischemia, probably via transient maldistribution of transmural perfusion. However, coronary blood flow rate does not independently modulate contractility after brief reversible ischemia.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
F. Wu, E. Y. Zhang, J. Zhang, R. J. Bache, and D. A. Beard
Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischaemic hearts
J. Physiol., September 1, 2008; 586(17): 4193 - 4208.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. Y. Wang, M. Friedman, R. G. Johnson, A. J. Zeind, and F. W. Sellke
ADENOSINE TRIPHOSPHATE-SENSITIVE K+ CHANNELS MEDIATE POSTCARDIOPLEGIA CORONARY HYPEREMIA
J. Thorac. Cardiovasc. Surg., October 1, 1995; 110(4): 1073 - 1082.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online