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Am J Physiol Heart Circ Physiol 261: H1945-H1950, 1991;
0363-6135/91 $5.00
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AJP - Heart and Circulatory Physiology, Vol 261, Issue 6 1945-H1950, Copyright © 1991 by American Physiological Society

ARTICLES

Parathyroid hormone: an endogenous modulator of cardiac calcium channels

D. Rampe, A. E. Lacerda, R. C. Dage and A. M. Brown
Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215.

We have tested the effects of the active 1-34 amino acid sequence of rat parathyroid hormone (PTH) on Ca2+ channel activity in neonatal rat ventricular cells. Rat PTH (30 pM to 10 nM) increased depolarization-induced Ca2+ influx into these cells, an effect that was abolished by 1 microM nifedipine. The 1-34 amino acid sequence of bovine PTH also stimulated Ca2+ influx in control cells but not in cells pretreated with cholera toxin. Rat PTH also elevated adenosine 3',5'-cyclic monophosphate accumulation in these ventricular myocytes. Whole cell voltage-clamp recordings confirmed a stimulatory effect of rat PTH on cardiac L-type Ca2+ channels. Cell-attached single channel recordings revealed an increase in the probability of channel opening as the primary mechanism for the enhancement of Ca2+ current. Taken together these results suggest an important role for PTH as an endogenous modulator of cardiac L-type Ca2+ channels.


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 Eur J Heart FailHome page
R. Meyer, R. Schreckenberg, F. Kretschmer, A. Bittig, C. Conzelmann, C. Grohe, and K.-D. Schluter
Parathyroid hormone-related protein (PTHrP) signal cascade modulates myocardial dysfunction in the pressure overloaded heart
Eur J Heart Fail, December 1, 2007; 9(12): 1156 - 1162.
[Abstract] [Full Text] [PDF]


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