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Am J Physiol Heart Circ Physiol 261: H1961-H1969, 1991;
0363-6135/91 $5.00
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AJP - Heart and Circulatory Physiology, Vol 261, Issue 6 1961-H1969, Copyright © 1991 by American Physiological Society

ARTICLES

Regional blood flow effects of ANP in conscious dogs: preferential gastrointestinal vasoconstriction

R. L. Woods and J. J. Smolich
Baker Medical Research Institute, Prahran, Victoria, Australia.

We studied total and regional blood flow responses to human atrial natriuretic peptide (alpha-hANP) using radioactive microspheres in six conscious dogs. Hemodynamic responses to infusions of alpha-hANP at 75 ng.kg-1.min-1 were determined in each dog in the presence and absence of autonomic reflexes using the ganglion blocking agent pentolinium. When autonomic reflexes were blocked, alpha-hANP caused a substantial reduction in gastrointestinal (GI) vascular conductance (35%) but had no significant effects in brain, kidneys, liver, skeletal muscle, or skin. This alpha-hANP-induced fall in GI conductance contributed more than 40% to the fall in total peripheral conductance (TPC) of 24% occurring after autonomic blockade. A fall in myocardial vascular conductance, most prominent in the left ventricle, contributed a further 40% to the fall in TPC. When autonomic reflexes were intact, alpha-hANP caused vasoconstriction in the GI region (29% fall in vascular conductance), had no significant effects on myocardial vascular conductance but significantly increased splenic vascular conductance. In addition to these systemic responses, alpha-hANP infusion also significantly reduced pulmonary vascular conductance, independent of autonomic reflex activity or changes in pulmonary artery pressure. Thus our results in conscious dogs demonstrate that alpha-hANP causes a systemic vasoconstriction, most pronounced in the GI region.


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