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Am J Physiol Heart Circ Physiol 262: H1449-H1457, 1992;
0363-6135/92 $5.00
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AJP - Heart and Circulatory Physiology, Vol 262, Issue 5 1449-H1457, Copyright © 1992 by American Physiological Society

ARTICLES

Differential recovery of prostacyclin and endothelium-derived relaxing factor after vascular injury

R. M. Saroyan, M. P. Roberts, J. T. Light Jr, I. L. Chen, M. Y. Vaccarella, D. J. Bang, P. Kvamme, S. Singh, S. V. Scalia, M. D. Kerstein and al. et
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112.

Differential recovery of prostacyclin and endothelium-derived relaxing factor after vascular injury. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H1449-H1457, 1992. The recovery of prostacyclin (prostaglandin I2, PGI2) synthesis and endothelium-derived relaxing factor (EDRF) activity, as demonstrated by acetylcholine (ACh)-induced relaxation, by rabbit aorta was examined up to 8 wk after balloon catheter-induced injury. Following injury, basal 6-keto-PGF1 alpha formation was decreased acutely; however, after 3 wk it was not different from control. Arachidonic acid-stimulated 6-keto-PGF1 alpha formation was decreased, returning to control levels at 3 and 8 wk for thoracic and abdominal aorta, respectively. ACh-induced relaxation did not return to control levels over the 8-wk study. Initiation of reendothelialization with a layer of hyperplastic endothelial cells overlying subendothelial fibrosis and intimal hyperplasia were present at 2-3 wk. Intimal hyperplasia appeared 2 wk after injury and progressed throughout the period of the study. These data indicate that following balloon catheter-induced injury the formation of both PGI2 and EDRF is reduced and that recovery follows a differential time course. In addition, the recovery of PGI2 formation did not coincide with the attenuation of intimal hyperplasia, whereas the relationship between EDRF formation and intimal hyperplasia is uncertain.


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