| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 263, Issue 4 1190-H1196, Copyright © 1992 by American Physiological Society
ARTICLES |
H. Nielsen, J. M. Hasenkam, H. K. Pilegaard, C. Aalkjaer and F. V. Mortensen
Institute of Pharmacology, Skejby Sygehus, Aarhus, Denmark.
Human subcutaneous resistance arteries (122-298 microns), isolated from 139 patients undergoing surgery, were mounted in an isometric myograph. With the use of multiple regression analysis, five different modes of activation were examined for possible associations with age and mean arterial blood pressure of the patients: the contractile responses to 10 microM norepinephrine (mixed alpha 1-agonist/alpha 2-agonist), perivascular nerve stimulation, 10 microM phenylephrine (alpha 1-agonist), 100 microM B-HT 933 (alpha 2-agonist), and depolarization by potassium chloride. Blood pressure increased significantly with age. Blood pressure independently was not correlated to any mode of activation. With increasing patient age, however, responses to norepinephrine, phenylephrine, and perivascular nerve stimulation decreased, whereas the response to B-HT 933 increased; responses to potassium chloride were unaltered. Also corrected for changes in blood pressure, age independently was negatively correlated to the response to norepinephrine and phenylephrine, whereas a positive, though nonsignificant (P value = 0.12), correlation was observed between age independently and the response to B-HT 933. These data suggest that the ability of isolated human resistance arteries to evoke contractions medicated by postjunctional alpha 1-, but not alpha 2-adrenoceptors, decreases with age.
This article has been cited by other articles:
|
|
 |
|
  S. Lavi, O. Nevo, I. Thaler, R. Rosenfeld, L. Dayan, N. Hirshoren, L. Gepstein, and G. Jacob Effect of aging on the cardiovascular regulatory systems in healthy women Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R788 - R793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Thompson, L. A. Holowatz, and W. L. Kenney Cutaneous vasoconstrictor responses to norepinephrine are attenuated in older humans Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1108 - R1113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Seals and F. A. Dinenno Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H1895 - H1905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Asai, R. K. Kudej, G. Takagi, A. B. Kudej, F. Natividad, Y.-T. Shen, D. E. Vatner, and S. F. Vatner Paradoxically Enhanced Endothelin-B Receptor-Mediated Vasoconstriction in Conscious Old Monkeys Circulation, May 15, 2001; 103(19): 2382 - 2386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Sullivan and C. A. Davison Gender Differences in the Effect of Age on Electrical Field Stimulation (EFS)-Induced Adrenergic Vasoconstriction in Rat Mesenteric Resistance Arteries J. Pharmacol. Exp. Ther., March 1, 2001; 296(3): 782 - 788. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Frank, S. N. Raja, C. Bulcao, and D. S. Goldstein Age-related thermoregulatory differences during core cooling in humans Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R349 - R354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Freedman and R. Girgis Effects of Menstrual Cycle and Race on Peripheral Vascular {alpha}-Adrenergic Responsiveness Hypertension, March 1, 2000; 35(3): 795 - 799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Olsen, E. Vernersson, and T. Lanne Cardiovascular response to acute hypovolemia in relation to age. Implications for orthostasis and hemorrhage Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H222 - H232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. Davy, D. R. Seals, and H. Tanaka Augmented Cardiopulmonary and Integrative Sympathetic Baroreflexes but Attenuated Peripheral Vasoconstriction With Age Hypertension, August 1, 1998; 32(2): 298 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Xu, D.-g. Li, N. J. Holbrook, and R. Udelsman Acute Hypertension Induces Heat-Shock Protein 70 Gene Expression in Rat Aorta Circulation, September 1, 1995; 92(5): 1223 - 1229. [Abstract] [Full Text]
|
|
|
|
|
|
J. Muller-Delp, S. A. Spier, M. W. Ramsey, L. A. Lesniewski, A. Papadopoulos, J. D. Humphrey, and M. D. Delp Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arterioles Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1843 - H1854. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
