AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 263: H1650-H1658, 1992;
0363-6135/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nakanishi, K.
Right arrow Articles by Johnston, W. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nakanishi, K.
Right arrow Articles by Johnston, W. E.

AJP - Heart and Circulatory Physiology, Vol 263, Issue 6 1650-H1658, Copyright © 1992 by American Physiological Society

ARTICLES

Intracoronary L-arginine during reperfusion improves endothelial function and reduces infarct size

K. Nakanishi, J. Vinten-Johansen, D. J. Lefer, Z. Zhao, W. C. Fowler 3rd, D. S. McGee and W. E. Johnston
Department of Cardiothoracic Surgery, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157.

We tested the hypothesis that intracoronary administration of L-arginine (L-Arg), the physiological nitric oxide (NO) precursor, during reperfusion would attenuate postischemic damage by L-Arg NO-pathway mechanisms. Open-chest, anesthetized dogs underwent 60 min of left anterior descending coronary arterial (LAD) occlusion followed by 270 min of reperfusion. Dogs received intracoronary 10 mM L-Arg (n = 9 dogs), intracoronary 10 mM D-arginine (D-Arg, n = 7), or saline vehicle (Veh, n = 10) in the LAD during the first 120 min of reperfusion using an extracorporeal system. After 270 min of reperfusion, segmental systolic and diastolic function were comparably impaired in all three groups. Infarct size (triphenyltetrazolium chloride) expressed as a percentage of the area at risk (An/Ar) was significantly (P < 0.05) reduced in the L-Arg group (17.7 +/- 3.2%) compared with the Veh group (34.8 +/- 2.4%); D-Arg reversed this cardioprotection (48.8 +/- 5.2%, P < 0.05 vs. L-Arg, Veh). Cardiac myeloperoxidase activity, an index of neutrophil accumulation (U/100 mg tissue), was significantly (P < 0.05) lower in the necrotic tissue of the L-Arg group (0.88 +/- 0.26) than in the Veh group (2.46 +/- 0.38). Furthermore, responses to endothelium-dependent vasodilators acetylcholine and A23187 in isolated ischemic-reperfused LAD rings were significantly (P < 0.05) greater in the L-Arg group than in the other two groups. We conclude that intracoronary infusion of L-Arg during the early phase of reperfusion reduced neutrophil accumulation and infarct size and the infusion preserved endothelial function, possibly by increasing NO release or production by the endothelium.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W.-Y. Lin, R. M. Levin, P. Chichester, R. Leggett, Y.-S. Juan, A. Johnson, P. Neumann, C. Whitbeck, A. Guven, B. Kogan, et al.
Effects of L-arginine and L-NAME on chronic partial bladder outlet obstruction in rabbit
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2390 - R2399.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. E. Darling, R. Jiang, M. Maynard, P. Whittaker, J. Vinten-Johansen, and K. Przyklenk
Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: role of ERK1/2
Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1618 - H1626.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Q. Qin, X.-M. Yang, L. Cui, S. D. Critz, M. V. Cohen, N. C. Browner, T. M. Lincoln, and J. M. Downey
Exogenous NO triggers preconditioning via a cGMP- and mitoKATP-dependent mechanism
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H712 - H718.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. T. Gonon, D. Erbas, A. Broijersen, G. Valen, and J. Pernow
Nitric oxide mediates protective effect of endothelin receptor antagonism during myocardial ischemia and reperfusion
Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1767 - H1774.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. P. Jones, J. J. M. Greer, A. K. Kakkar, P. D. Ware, R. H. Turnage, M. Hicks, R. van Haperen, R. de Crom, S. Kawashima, M. Yokoyama, et al.
Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury
Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H276 - H282.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. Muraki, C. D. Morris, J. M. Budde, Z.-Q. Zhao, R. A. Guyton, and J. Vinten-Johansen
Blood cardioplegia supplementation with the sodium-hydrogen ion exchange inhibitor cariporide to attenuate infarct size and coronary artery endothelial dysfunction after severe regional ischemia in a canine model
J. Thorac. Cardiovasc. Surg., January 1, 2003; 125(1): 155 - 164.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. R. Sharp, S. P. Jones, D. M. Rimmer, and D. J. Lefer
Differential response to myocardial reperfusion injury in eNOS-deficient mice
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2422 - H2426.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Shiono, V. Rao, R. D. Weisel, M. Kawasaki, R.-K. Li, D. A. G. Mickle, P. W. M. Fedak, L. C. Tumiati, L. Ko, and S. Verma
L-Arginine protects human heart cells from low-volume anoxia and reoxygenation
Am J Physiol Heart Circ Physiol, March 1, 2002; 282(3): H805 - H815.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. Muraki, C. D. Morris, J. M. Budde, R. N. Otto, Z.-Q. Zhao, J. D. Puskas, R. A. Guyton, and J. Vinten-Johansen
Preserved myocardial blood flow and oxygen supply-demand balance with active coronary perfusion during simulated off-pump coronary artery bypass grafting
J. Thorac. Cardiovasc. Surg., January 1, 2002; 123(1): 53 - 62.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. A. Schriefer, E. P. Broudy, and A. H. Hassen
Inhibitors of Bradykinin-Inactivating Enzymes Decrease Myocardial Ischemia/Reperfusion Injury following 3 and 7 Days of Reperfusion
J. Pharmacol. Exp. Ther., September 1, 2001; 298(3): 970 - 975.
[Abstract] [Full Text]

Home page
 CirculationHome page
R. K. Kharbanda, M. Peters, B. Walton, M. Kattenhorn, M. Mullen, N. Klein, P. Vallance, J. Deanfield, and R. MacAllister
Ischemic Preconditioning Prevents Endothelial Injury and Systemic Neutrophil Activation During Ischemia-Reperfusion in Humans In Vivo
Circulation, March 27, 2001; 103(12): 1624 - 1630.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. Muraki, C. D. Morris, J. M. Budde, D. A. Velez, Z.-Q. Zhao, R. A. Guyton, and J. Vinten-Johansen
Experimental off-pump coronary artery revascularization with adenosine-enhanced reperfusion
J. Thorac. Cardiovasc. Surg., March 1, 2001; 121(3): 570 - 579.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Nagashima, G. Nollert, U. Stock, J. Sperling, S. Hatsuoka, D. Shum-Tim, K. Takeuchi, A. Nedder, and J. E. Mayer Jr
Cardiac performance after deep hypothermic circulatory arrest in chronically cyanotic neonatal lambs
J. Thorac. Cardiovasc. Surg., August 1, 2000; 120(2): 238 - 246.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
N. Sasaki, T. Sato, A. Ohler, B. O’Rourke, and E. Marban
Activation of Mitochondrial ATP-Dependent Potassium Channels by Nitric Oxide
Circulation, February 1, 2000; 101(4): 439 - 445.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Shinmura, X.-L. Tang, H. Takano, M. Hill, and R. Bolli
Nitric oxide donors attenuate myocardial stunning in conscious rabbits
Am J Physiol Heart Circ Physiol, December 1, 1999; 277(6): H2495 - H2503.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
D. K. Das, R. M. Engelman, N. Maulik, J. A. Rousou, J. E. Flack III, and D. W. Deaton
Molecular targets of gene therapy
Ann. Thorac. Surg., November 1, 1999; 68(5): 1929 - 1933.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
X.-P. Yang, Y.-H. Liu, E. G. Shesely, M. Bulagannawar, F. Liu, and O. A. Carretero
Endothelial Nitric Oxide Gene Knockout Mice : Cardiac Phenotypes and the Effect of Angiotensin-Converting Enzyme Inhibitor on Myocardial Ischemia/Reperfusion Injury
Hypertension, July 1, 1999; 34(1): 24 - 30.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. R. Kersten and D. C. Warltier
Modulation of the adaptive response to myocardial ischemia by coexisting disease
Am J Physiol Heart Circ Physiol, June 1, 1999; 276(6): H2268 - H2270.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. P. Jones, W. G. Girod, A. J. Palazzo, D. N. Granger, M. B. Grisham, D. Jourd'Heuil, P. L. Huang, and D. J. Lefer
Myocardial ischemia-reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase
Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1567 - H1573.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. Xi, N. C. Jarrett, M. L. Hess, and R. C. Kukreja
Essential Role of Inducible Nitric Oxide Synthase in Monophosphoryl Lipid A–Induced Late Cardioprotection : Evidence From Pharmacological Inhibition and Gene Knockout Mice
Circulation, April 27, 1999; 99(16): 2157 - 2163.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. K. Angele, N. Smail, M. W. Knoferl, A. Ayala, W. G. Cioffi, and I. H. Chaudry
L-Arginine restores splenocyte functions after trauma and hemorrhage potentially by improving splenic blood flow
Am J Physiol Cell Physiol, January 1, 1999; 276(1): C145 - C151.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. Takano, S. Manchikalapudi, X.-L. Tang, Y. Qiu, A. Rizvi, A. K. Jadoon, Q. Zhang, and R. Bolli
Nitric Oxide Synthase Is the Mediator of Late Preconditioning Against Myocardial Infarction in Conscious Rabbits
Circulation, August 4, 1998; 98(5): 441 - 449.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. Takano, X.-L. Tang, Y. Qiu, Y. Guo, B. A. French, and R. Bolli
Nitric Oxide Donors Induce Late Preconditioning Against Myocardial Stunning and Infarction in Conscious Rabbits via an Antioxidant-Sensitive Mechanism
Circ. Res., July 13, 1998; 83(1): 73 - 84.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. Mizuno, M. Watanabe, T. Sakamoto, and M. Sunamori
L-Arginine, a nitric oxide precursor, attenuates ischemia-reperfusion injury by inhibiting inositol-1,4,5-triphosphate
J. Thorac. Cardiovasc. Surg., April 1, 1998; 115(4): 931 - 936.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. C. Sheridan, R. C. McIntyre Jr., D. R. Meldrum, and D. A. Fullerton
L-Arginine prevents lung neutrophil accumulation and preserves pulmonary endothelial function after endotoxin
Am J Physiol Lung Cell Mol Physiol, March 1, 1998; 274(3): L337 - L342.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. R. Meldrum
Tumor necrosis factor in the heart
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R577 - R595.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. W. Horton, J. White, D. Maass, and B. Sanders
Arginine in burn injury improves cardiac performance and prevents bacterial translocation
J Appl Physiol, February 1, 1998; 84(2): 695 - 702.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. Fei, A. D. Baron, D. P. Henry, and D. P. Zipes
Intrapericardial Delivery of L-Arginine Reduces the Increased Severity of Ventricular Arrhythmias During Sympathetic Stimulation in Dogs With Acute Coronary Occlusion : Nitric Oxide Modulates Sympathetic Effects on Ventricular Electrophysiological Properties
Circulation, December 2, 1997; 96(11): 4044 - 4049.
[Abstract] [Full Text]

Home page
 CirculationHome page
D. F. Stowe, M. Boban, D. L. Roerig, D. Chang, B. W. Palmisano, and Z. J. Bosnjak
Effects of L-Arginine and N{omega}-Nitro-L-Arginine Methyl Ester on Cardiac Perfusion and Function After 1-Day Cold Preservation of Isolated Hearts
Circulation, March 18, 1997; 95(6): 1623 - 1634.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. Sato, Z.-Q. Zhao, J. E. Jordan, J. C. Todd, R. D. Riley, C. S. Taft, J. W. Hammon Jr., P. Li, X.-l. Ma, and J. Vinten-Johansen
BASAL NITRIC OXIDE EXPRESSES ENDOGENOUS CARDIOPROTECTION DURING REPERFUSION BY INHIBITION OF NEUTROPHIL-MEDIATED DAMAGE AFTER SURGICAL REVASCULARIZATION
J. Thorac. Cardiovasc. Surg., February 1, 1997; 113(2): 399 - 409.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
Y. Shiraishi, J. R. Lee, H. Laks, P. F. Waters, A. Meneshian, A. Blitz, K. Johnson, L. Lam, and P. A. Chang
L-Arginine Administration During Reperfusion Improves Pulmonary Function
Ann. Thorac. Surg., December 1, 1996; 62(6): 1580 - 1586.
[Abstract] [Full Text]

Home page
 CirculationHome page
R. W. Jeremy, H. McCarron, and D. Sullivan
Effects of Dietary L-Arginine on Atherosclerosis and Endothelium-Dependent Vasodilatationin the Hypercholesterolemic Rabbit: Response According to Treatment Duration, Anatomic Site, and Sex
Circulation, August 1, 1996; 94(3): 498 - 506.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
R. Pabla, A. J. Buda, D. M. Flynn, S. A. Blesse, A. M. Shin, M. J. Curtis, and D. J. Lefer
Nitric Oxide Attenuates Neutrophil-Mediated Myocardial Contractile Dysfunction After Ischemia and Reperfusion
Circ. Res., January 1, 1996; 78(1): 65 - 72.
[Abstract] [Full Text]

Home page
 HypertensionHome page
Y.-H. Liu, X.-P. Yang, V. G. Sharov, D. H. Sigmon, H. N. Sabbah, and O. A. Carretero
Paracrine Systems in the Cardioprotective Effect of Angiotensin-Converting Enzyme Inhibitors on Myocardial Ischemia/Reperfusion Injury in Rats
Hypertension, January 1, 1996; 27(1): 7 - 13.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
D. T. Engelman, M. Watanabe, R. M. Engelman, J. A. Rousou, J. E. Flack III, D. W. Deaton, and D. K. Das
CONSTITUTIVE NITRIC OXIDE RELEASE IS IMPAIRED AFTER ISCHEMIA AND REPERFUSION
J. Thorac. Cardiovasc. Surg., October 1, 1995; 110(4): 1047 - 1053.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. Sato, Z.-Q. Zhao, D. S. McGee, M. W. Williams, J. W. Hammon Jr., and J. Vinten-Johansen
SUPPLEMENTAL L-ARGININE DURING CARDIOPLEGIC ARREST AND REPERFUSION AVOIDS REGIONAL POSTISCHEMIC INJURY
J. Thorac. Cardiovasc. Surg., August 1, 1995; 110(2): 302 - 314.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. Hiramatsu, J. M. Forbess, T. Miura, F. Nomura, and J. E. Mayer Jr.
Additive effects of L-arginine infusion and leukocyte depletion on recovery after hypothermic ischemia in neonatal lamb hearts
J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 172 - 179.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
K. Nakanishi, Z.-Q. Zhao, J. Vinten-Johansen, D. A. Hudspeth, D. S. McGee, and J. W. Hammon Jr.
Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction
J. Thorac. Cardiovasc. Surg., June 1, 1995; 109(6): 1146 - 1154.
[Abstract] [Full Text]

Home page
 CirculationHome page
P. R. Hansen
Role of Neutrophils in Myocardial Ischemia and Reperfusion
Circulation, March 15, 1995; 91(6): 1872 - 1885.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
Y. Naka, N. C. Chowdhury, M. C. Oz, C. R. Smith, O. J. Yano, R. E. Michler, D. M. Stern, and D. J. Pinsky
Nitroglycerin maintains graft vascular homeostasis and enhances preservation in an orthotopic rat lung transplant model
J. Thorac. Cardiovasc. Surg., February 1, 1995; 109(2): 206 - 211.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. Hiramatsu, J. M. Forbess, T. Miura, and J. E. Mayer Jr.
Effects of L-Arginine and L-nitro-arginine methyl ester on recovery of neonatal lamb hearts after cold ischemiaEvidence for an important role of endothelial production of nitric oxide
J. Thorac. Cardiovasc. Surg., January 1, 1995; 109(1): 81 - 87.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Nakanishi, J. Vinten-Johansen, D. J. Lefer, Z. Zhao, W. C. Fowler 3rd, D. S. McGee, and W. E. Johnston
Intracoronary L-arginine during reperfusion improves endothelial function and reduces infarct size
Am J Physiol Heart Circ Physiol, December 1, 1992; 263(6): H1650 - H1658.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. R. Sharp, S. P. Jones, D. M. Rimmer, and D. J. Lefer
Differential response to myocardial reperfusion injury in eNOS-deficient mice
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2422 - H2426.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online