AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 263: H1724-H1731, 1992;
0363-6135/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McFalls, E. O.
Right arrow Articles by Verdouw, P. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McFalls, E. O.
Right arrow Articles by Verdouw, P. D.

AJP - Heart and Circulatory Physiology, Vol 263, Issue 6 1724-H1731, Copyright © 1992 by American Physiological Society

ARTICLES

Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium

E. O. McFalls, D. J. Duncker, R. Krams, L. M. Sassen, A. Hoogendoorn and P. D. Verdouw
Laboratory for Experimental Cardiology (Thoraxcenter), Erasmus University Rotterdam, The Netherlands.

We characterized postischemic changes in myocardial metabolism and regional external work, as measured by the integral of left ventricular pressure-segment-length loops. In 12 anesthetized swine, the left anterior descending coronary artery (LAD) was occluded for 10 min and reperfused for 30 min for two successive cycles. Before ischemia, regional work was 16,920 +/- 5,630 mmHg-mm/min and after stunning, work was reduced to 50 +/- 14% (P < 0.05). At baseline, oxygen and lactate consumption were 4.80 +/- 1.40 and 1.02 +/- 0.46 mumol.min-1 x g-1, respectively, and after stunning they were reduced to 3.24 +/- 0.80 (P < 0.05) and 0.16 +/- 0.21 mumol.min-1 x g-1 (P < 0.05), respectively. The atria were then paced 50 beats/min higher than the reperfusion heart rate, during and without an infusion of dobutamine (2 micrograms.kg-1 x min-1). During dobutamine, both regional external work and oxygen consumption returned to 98% of preischemic values, but lactate utilization remained depressed. We conclude that regional external work and oxygen consumption remain coupled during inotropic stimulation after stunning, with a preferential shift toward nonlactate substrates.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. N. Mazzadi, X. Andre-Fouet, N. Costes, P. Croisille, D. Revel, and M. F. Janier
Mechanisms leading to reversible mechanical dysfunction in severe CAD: alternatives to myocardial stunning
Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2570 - H2582.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. J. Sherman, F. J. Klocke, R. S. Decker, M. L. Decker, K. A. Kozlowski, K. R. Harris, S. Hedjbeli, Y. Yaroshenko, S. Nakamura, M. A. Parker, et al.
Myofibrillar disruption in hypocontractile myocardium showing perfusion-contraction matches and mismatches
Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1320 - H1334.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. O. McFalls, D. Baldwin, D. Marx, P. Fashingbauer, and H. B. Ward
Effect of regional hyperemia on myocardial uptake of 2-deoxy-2-[18F]fluoro-D-glucose
Am J Physiol Endocrinol Metab, January 1, 2000; 278(1): E96 - E102.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Murakami, J. Zhang, M. H. J. Eijgelshoven, W. Chen, W. C. Carlyle, Y. Zhang, G. Gong, and R. J. Bache
Myocardial creatine kinase kinetics in hearts with postinfarction left ventricular remodeling
Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H892 - H900.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online