AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 263: H1739-H1746, 1992;
0363-6135/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schluter, K. D.
Right arrow Articles by Piper, H. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schluter, K. D.
Right arrow Articles by Piper, H. M.

AJP - Heart and Circulatory Physiology, Vol 263, Issue 6 1739-H1746, Copyright © 1992 by American Physiological Society

ARTICLES

Trophic effects of catecholamines and parathyroid hormone on adult ventricular cardiomyocytes

K. D. Schluter and H. M. Piper
Physiologisches Institut I, Universitat Dusseldorf, Federal Republic of Germany.

Trophic effects of isoproterenol (Iso), norepinephrine (NE), phenylephrine (PE), and biologically active fragments of parathyroid hormone (PTH), PTH-(1-34) and PTH-(28-48), were investigated in mechanically quiescent, isolated ventricular cardiomyocytes from adult rat. In 24-h incubations in modified serum-free medium 199 incorporation of [14C]phenylalanine, changes in total protein and specific activities of cytosolic enzymes, creatine kinase (CK) and lactate dehydrogenase (LDH) were monitored. NE and PE (10 microM), but not Iso, distinctly increased phenylalanine incorporation, total cell protein, and specific activity of CK but not LDH. Induction of CK, but not LDH, was also produced by phorbol 12-myristate 13-acetate (10 nM) but not dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP, 1 mM). It was abolished by copresence of cycloheximide (35 microM) or actinomycin D (5 microM). CK-BB was the only induced isoform of CK, as shown for PE incubations. PTH-(1-34) and PTH-(28-48) (30-300 nM) had effects comparable to NE and PE. They increased phenylalanine incorporation and total protein content and induced CK but not LDH. In summary, distinct trophic effects on adult cardiomyocytes were found with alpha 1-adrenergic agonists, fragments of PTH containing the midregional amino acids 28-34, and direct activation of protein kinase C but neither beta-adrenergic agonists nor DBcAMP.


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
A. Salameh, S. Krautblatter, S. Baessler, S. Karl, D. R. Gomez, S. Dhein, and D. Pfeiffer
Signal Transduction and Transcriptional Control of Cardiac Connexin43 Up-Regulation after {alpha}1-Adrenoceptor Stimulation
J. Pharmacol. Exp. Ther., July 1, 2008; 326(1): 315 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. R. Lee, D. Bell, E. J. Kelso, C. C. H. Argent, and B. J. McDermott
Evidence for altered ETB receptor characteristics during development and progression of ventricular cardiomyocyte hypertrophy
Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H425 - H432.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Kanevskij, G. Taimor, M. Schafer, H. M. Piper, and K.-D. Schluter
Neuropeptide Y modifies the hypertrophic response of adult ventricular cardiomyocytes to norepinephrine
Cardiovasc Res, March 1, 2002; 53(4): 879 - 887.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Schafer, K. Frischkopf, G. Taimor, H. M. Piper, and K.-D. Schluter
Hypertrophic effect of selective beta 1-adrenoceptor stimulation on ventricular cardiomyocytes from adult rat
Am J Physiol Cell Physiol, August 1, 2000; 279(2): C495 - C503.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
O.-E. Brodde and M. C. Michel
Adrenergic and Muscarinic Receptors in the Human Heart
Pharmacol. Rev., December 1, 1999; 51(4): 651 - 690.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
K.-D. SCHLUTER and H. M. PIPER
Regulation of growth in the adult cardiomyocytes
FASEB J, May 1, 1999; 13(9001): 17 - 22.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K.-D. Schluter, A. Simm, M. Schafer, G. Taimor, and H. M. Piper
Early response kinase and PI 3-kinase activation in adult cardiomyocytes and their role in hypertrophy
Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1655 - H1663.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Ehmke, J. Faulhaber, K. Munter, M. Kirchengast, and R. J. Wiesner
Chronic ETA Receptor Blockade Attenuates Cardiac Hypertrophy Independently of Blood Pressure Effects in Renovascular Hypertensive Rats
Hypertension, April 1, 1999; 33(4): 954 - 960.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. Alexandrov, S. Keffel, M. Goepel, and M. C. Michel
Stimulation of alpha 1A-Adrenoceptors in Rat-1 Cells Inhibits Extracellular Signal-Regulated Kinase by Activating p38 Mitogen-Activated Protein Kinase
Mol. Pharmacol., November 1, 1998; 54(5): 755 - 760.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Y. Goldberg, G. Taimor, H. M. Piper, and K.-D. Schluter
Intracellular signaling leads to the hypertrophic effect of neuropeptide Y
Am J Physiol Cell Physiol, November 1, 1998; 275(5): C1207 - C1215.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
P. Rouet-Benzineb, K. Mohammadi, J. Perennec, M. Poyard, N. El Houda Bouanani, and B. Crozatier
Protein Kinase C Isoform Expression in Normal and Failing Rabbit Hearts
Circ. Res., August 1, 1996; 79(2): 153 - 161.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online