| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 264, Issue 1 238-H243, Copyright © 1993 by American Physiological Society
ARTICLES |
W. F. Jackson, A. Konig, T. Dambacher and R. Busse
Department of Biological Sciences, College of Arts and Sciences, Western Michigan University, Kalamazoo 49008.
We tested the hypothesis that prostacyclin and its stable analogue iloprost act as agonists of ATP-sensitive potassium channels (KATP) to induce vasodilation of the coronary circulation. The selective blocker of KATP, glibenclamide, was used as a probe for vasodilation mediated by KATP in saline-perfused rabbit hearts (constant flow, Langendorff preparation). Glibenclamide (10-300 nM) significantly increased coronary perfusion pressure and inhibited vasodilation induced by iloprost (1-30 nM), prostacyclin (10 nM), adenosine (0.3 microM), and cromakalim (0.1 microM), a known agonist of KATP. This potassium channel antagonist also inhibited vasodilation of rabbit hearts in response to 10 nM bradykinin in the presence of an inhibitor of nitric oxide synthase (30 microM NG-nitro-L-arginine). Because bradykinin-induced vasodilation is mediated by prostacyclin released from endothelial cells when nitric oxide synthesis is inhibited, these data indicate that glibenclamide is also effective against endogenous prostacyclin. The inhibitory effects of glibenclamide were selective: vasodilation induced by sodium nitroprusside (1-10 microM) or acetylcholine (1 microM) were not inhibited by this potassium channel antagonist. In addition, basal and bradykinin-stimulated release of 6-ketoprostaglandin F1 alpha was not affected by this antagonist of KATP. Glibenclamide also did not inhibit the activation of adenylate cyclase, as indicated by its lack of effect on adenosine 3',5'-cyclic monophosphate accumulation induced by iloprost (10 nM-1 microM) in bovine coronary arterial segments, a tissue in which iloprost-induced vascular smooth muscle relaxation is inhibited by glibenclamide.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  D. J. Duncker and R. J. Bache Regulation of Coronary Blood Flow During Exercise Physiol Rev, July 1, 2008; 88(3): 1009 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wareing, X. Bai, F. Seghier, C. M. Turner, S. L. Greenwood, P. N. Baker, M. J. Taggart, and G. K. Fyfe Expression and function of potassium channels in the human placental vasculature Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R437 - R446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Merkus, D. B. Haitsma, T.-Y. Fung, Y. J. Assen, P. D. Verdouw, and D. J. Duncker Coronary blood flow regulation in exercising swine involves parallel rather than redundant vasodilator pathways Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H424 - H433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. O. Farouque and I. T. Meredith Relative contribution of vasodilator prostanoids, NO, and KATP channels to human forearm metabolic vasodilation Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2405 - H2411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. O. Farouque and I. T. Meredith Inhibition of vascular ATP-sensitive K+ channels does not affect reactive hyperemia in human forearm Am J Physiol Heart Circ Physiol, February 1, 2003; 284(2): H711 - H718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Erdos, A. W. Miller, and D. W. Busija Alterations in KATP and KCa channel function in cerebral arteries of insulin-resistant rats Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2472 - H2477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Stavrou, D. J. Sheridan, and N. A. Flores Contribution of Nitric Oxide and Prostanoids to the Cardiac Electrophysiological and Coronary Vasomotor Effects of Diadenosine Polyphosphates J. Pharmacol. Exp. Ther., August 1, 2001; 298(2): 531 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. F. Jackson Ion Channels and Vascular Tone Hypertension, January 1, 2000; 35(1): 173 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Richmond, J. D. Tune, M. W. Gorman, and E. O. Feigl Role of K+ATP channels in local metabolic coronary vasodilation Am J Physiol Heart Circ Physiol, December 1, 1999; 277(6): H2115 - H2123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Hein and L. Kuo cAMP-Independent Dilation of Coronary Arterioles to Adenosine : Role of Nitric Oxide, G Proteins, and KATP Channels Circ. Res., October 1, 1999; 85(7): 634 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Pelligrino, R. A. Santizo, and Q. Wang Miconazole represses CO2-induced pial arteriolar dilation only under selected circumstances Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1484 - H1490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Lombard, Y. Liu, K. T. Fredricks, D. M. Bizub, R. J. Roman, and N. J. Rusch Electrical and mechanical responses of rat middle cerebral arteries to reduced PO2 and prostacyclin Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H509 - H516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Hardy, D. Abran, X. Hou, I. Lahaie, K. G. Peri, P. Asselin, D. R. Varma, and S. Chemtob A Major Role for Prostacyclin in Nitric Oxide–Induced Ocular Vasorelaxation in the Piglet Circ. Res., October 5, 1998; 83(7): 721 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. N. Mutafova-Yambolieva and K. D. Keef Adenosine-induced hyperpolarization in guinea pig coronary artery involves A2b receptors and KATP channels Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2687 - H2695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Ming, R. Parent, and M. Lavallee ß2-Adrenergic Dilation of Resistance Coronary Vessels Involves KATP Channels and Nitric Oxide in Conscious Dogs Circulation, March 18, 1997; 95(6): 1568 - 1576. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. E. Freedman and Y.-J. Lin REVIEW {blacksquare} : ATP-sensitive Potassium Channels: Diverse Functions in the Central Nervous System Neuroscientist, May 1, 1996; 2(3): 145 - 152. [Abstract] [PDF]
|
|
|
|
|
|
T. Nagao, S. Ibayashi, S. Sadoshima, K. Fujii, K. Fujii, Y. Ohya, and M. Fujishima Distribution and Physiological Roles of ATP-Sensitive K+ Channels in the Vertebrobasilar System of the Rabbit Circ. Res., February 1, 1996; 78(2): 238 - 243. [Abstract] [Full Text]
|
|
|
|
|
|
R. A. Cohen and P. M. Vanhoutte Endothelium-Dependent Hyperpolarization : Beyond Nitric Oxide and Cyclic GMP Circulation, December 1, 1995; 92(11): 3337 - 3349. [Full Text]
|
|
|
|
|
|
N. L. Weintraub, A. H. Stephenson, R. S. Sprague, L. McMurdo, and A. J. Lonigro Relationship of Arachidonic Acid Release to Porcine Coronary Artery Relaxation Hypertension, October 1, 1995; 26(4): 684 - 690. [Abstract] [Full Text]
|
|
|
|
|
|
J. Tateishi and J. E. Faber ATP-Sensitive K+ Channels Mediate {alpha}2D-Adrenergic Receptor Contraction of Arteriolar Smooth Muscle and Reversal of Contraction by Hypoxia Circ. Res., January 1, 1995; 76(1): 53 - 63. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
