AJP - Heart Calcium Transients and Cell-Sarcomere
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Am J Physiol Heart Circ Physiol 264: H1472-H1477, 1993;
0363-6135/93 $5.00
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AJP - Heart and Circulatory Physiology, Vol 264, Issue 5 1472-H1477, Copyright © 1993 by American Physiological Society

ARTICLES

A stable L-arginine-dependent relaxing factor released from cytotoxic-activated macrophages

H. Uchizumi, R. Hattori, K. Sase, W. J. Cai, K. Kadota, S. Sasayama, C. Kawai and Y. Yui
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.

It has been known that cytotoxic-activated macrophages release an unstable vasorelaxing substance, nitric oxide. We have found that a more stable relaxing factor is released from those cells. This factor seems to be synthesized from L-arginine. It acts through the activation of soluble guanylate cyclase without affecting membrane potential. It has little charge at nearly neutral pH, and its molecular weight is < 500.


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