AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 265: H139-H145, 1993;
0363-6135/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liben, S.
Right arrow Articles by Perreault, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liben, S.
Right arrow Articles by Perreault, T.

AJP - Heart and Circulatory Physiology, Vol 265, Issue 1 139-H145, Copyright © 1993 by American Physiological Society

ARTICLES

Ontogeny of Big endothelin-1 effects in newborn piglet pulmonary vasculature

S. Liben, D. J. Stewart, J. De Marte and T. Perreault
Department of Pediatrics, Montreal Children's Hospital, Quebec, Canada.

Endothelin-1 (ET-1), a 21-amino acid peptide produced by endothelial cells, results from the cleavage of preproendothelin, generating Big ET-1, which is then cleaved by the ET-converting enzyme (ECE) to form ET-1. Big ET-1, like ET-1, is released by endothelial cells. Big ET-1 is equipotent to ET-1 in vivo, whereas its vasoactive effects are less in vitro. It has been suggested that the effects of Big ET-1 depend on its conversion to ET-1. ET-1 has potent vasoactive effects in the newborn pig pulmonary circulation, however, the effects of Big ET-1 remain unknown. Therefore, we studied the effects of Big ET-1 in isolated perfused lungs from 1- and 7-day-old piglets using the ECE inhibitor, phosphoramidon, and the ETA receptor antagonist, BQ-123Na. The rate of conversion of Big ET-1 to ET-1 was measured using radioimmunoassay. ET-1 (10(-13) to 10(-8) M) produced an initial vasodilation, followed by a dose-dependent potent vasoconstriction (P < 0.001), which was equal at both ages. Big ET-1 (10(-11) to 10(-8) M) also produced a dose-dependent vasoconstriction (P < 0.001). The constrictor effects of Big ET-1 and ET-1 were similar in the 1-day-old, whereas in the 7-day-old, the constrictor effect of Big ET-1 was less than that of ET-1 (P < 0.017).(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 J. Histochem. Cytochem.Home page
L. Guembe and A. C. Villaro
Immunohistochemical Mapping of Endothelin in the Developing and Adult Mouse Lung
J. Histochem. Cytochem., October 1, 2001; 49(10): 1301 - 1310.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Dunbar Ivy, T. D. Le Cras, M. P. Horan, and S. H. Abman
Increased lung preproET-1 and decreased ETB-receptor gene expression in fetal pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol, April 1, 1998; 274(4): L535 - L541.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. Aharinejad, D. E. Schraufnagel, A. Miksovsky, E. K. Larson, and S. C. Marks Jr.
Endothelin-1 focally constricts pulmonary veins in rats
J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 148 - 156.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online