AJP - Heart and Circulatory Physiology, Vol 265, Issue 1 146-H151, Copyright © 1993 by American Physiological Society

ARTICLES

Differences in EDNO contribution to arteriolar diameters at rest and during functional dilation in striated muscle

R. L. Hester, A. Eraslan and Y. Saito
Department of Physiology, University of Mississippi Medical Center, Jackson 39216-4505.

This study was designed to determine the physiological role of endothelium-dependent nitric oxide (EDNO) in the control of arteriolar diameter during rest and muscle stimulation. Diameters of first-, second-, and third-order arterioles in the superfused hamster cremaster muscle were measured before and throughout 1 min of field stimulation before and after inhibition of EDNO release. ENDO inhibition by intravenous N omega-nitro-L-arginine methyl ester (L-NAME) significantly attenuated the arteriolar vasodilation in response to 1 microM acetylcholine. First-order arterioles averaged 65 +/- 5 microns at rest and dilated to 86 +/- 6 microns during muscle stimulation (n = 9), second-order arterioles averaged 45 +/- 6 microns and dilated to 72 +/- 3 microns during muscle stimulation (n = 6), with third-order arterioles averaging 29 +/- 2 microns, and dilating to 53 +/- 3 microns during muscle stimulation (n = 7). EDNO inhibition significantly decreased both the resting diameter of first-order arterioles (57 +/- 4 microns) and functional dilation (68 +/- 3 microns; P < 0.05). EDNO inhibition had no effect on the resting diameter of second-order arterioles (45 +/- 5 microns) yet significantly attenuated the functional dilation (64 +/- 4 microns; P < 0.05). EDNO inhibition had no effect on either the resting diameter of third-order arterioles (30 +/- 2 microns) or the functional dilation (49 +/- 2 microns).(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				A. Lo, A. J. Fuglevand, and T. W. Secomb Theoretical simulation of K+-based mechanisms for regulation of capillary perfusion in skeletal muscle Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H833 - H840. [Abstract] [Full Text] [PDF]

				P. S. Clifford and Y. Hellsten Vasodilatory mechanisms in contracting skeletal muscle J Appl Physiol, July 1, 2004; 97(1): 393 - 403. [Abstract] [Full Text] [PDF]

				H. M. O. Farouque and I. T. Meredith Relative contribution of vasodilator prostanoids, NO, and KATP channels to human forearm metabolic vasodilation Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2405 - H2411. [Abstract] [Full Text] [PDF]

				D. Green, C. Cheetham, C. Henderson, R. Weerasooriya, and G. O'Driscoll Effect of cardiac pacing on forearm vascular responses and nitric oxide function Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1354 - H1360. [Abstract] [Full Text] [PDF]

				D. Green, C. Cheetham, L. Mavaddat, K. Watts, M. Best, R. Taylor, and G. O'Driscoll Effect of lower limb exercise on forearm vascular function: contribution of nitric oxide Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H899 - H907. [Abstract] [Full Text] [PDF]

				C. L. Murrant and I. H. Sarelius Multiple dilator pathways in skeletal muscle contraction-induced arteriolar dilations Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R969 - R978. [Abstract] [Full Text] [PDF]

				H. T. Yang, J. Ren, M. H. Laughlin, and R. L. Terjung Prior exercise training produces NO-dependent increases in collateral blood flow after acute arterial occlusion Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H301 - H310. [Abstract] [Full Text] [PDF]

				R. W. GRANGE, E. ISOTANI, K. S. LAU, K. E. KAMM, P. L. HUANG, and J. T. STULL Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles Physiol Genomics, February 7, 2001; 5(1): 35 - 44. [Abstract] [Full Text] [PDF]

				B. T. Ameredes and M. A. Provenzano Influence of nitric oxide on vascular resistance and muscle mechanics during tetanic contractions in situ J Appl Physiol, July 1, 1999; 87(1): 142 - 151. [Abstract] [Full Text] [PDF]

				U. Pohl and C. de Wit A Unique Role of NO in the Control of Blood Flow Physiology, April 1, 1999; 14(2): 74 - 80. [Abstract] [Full Text] [PDF]

				S. Shastry, N. M. Dietz, J. R. Halliwill, A. S. Reed, and M. J. Joyner Effects of nitric oxide synthase inhibition on cutaneous vasodilation during body heating in humans J Appl Physiol, September 1, 1998; 85(3): 830 - 834. [Abstract] [Full Text] [PDF]

				D. P. Thomas, O. Hudlicka, M. D. Brown, and D. Deveci Alterations in small arterioles precede changes in limb skeletal muscle after myocardial infarction Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H1032 - H1039. [Abstract] [Full Text] [PDF]

				J. M. Lash and H. G. Bohlen Time- and order-dependent changes in functional and NO-mediated dilation during exercise training J Appl Physiol, February 1, 1997; 82(2): 460 - 468. [Abstract] [Full Text] [PDF]

				M. K. McKay and R. L. Hester Role of Nitric Oxide, Adenosine, and ATP-Sensitive Potassium Channels in Insulin-Induced Vasodilation Hypertension, August 1, 1996; 28(2): 202 - 208. [Abstract] [Full Text]