| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 265, Issue 1 219-H225, Copyright © 1993 by American Physiological Society
ARTICLES |
H. G. Bohlen and J. M. Lash
Department of Physiology and Biophysics, Indiana University Medical School, Indianapolis 46122.
Arteriolar dilation to endothelium-derived relaxing factor (EDRF) is suppressed early in diabetes mellitus. The purpose of this study was to determine whether acute exposure to a hyperglycemic media can suppress EDRF function of normal arterioles. Dilation of intestinal arterioles to iontophoretically applied acetylcholine (ACh) and nitroprusside was measured in normoglycemic rats before and after 1 h of topical exposure to isotonic solutions containing D-glucose concentrations of 200, 300, and 500 mg/100 ml. Exposure to a D-glucose concentration of 200 mg/100 ml had no effect on vasodilation to ACh. D-Glucose concentrations of both 300 and 500 mg/100 ml caused significant suppression of the responses: for example, at the approximate 50% effective dosage (100 nA), the dilatory response was decreased by 60% at a D-glucose concentration of 300 mg/100 ml and 55% at a D-glucose concentration of 500 mg/100 ml. Responses to nitroprusside were not significantly (P < 0.05) impaired after exposure to D-glucose concentrations of 200, 300, or 500 mg/100 ml. Exposure to an isotonic L-glucose concentration of 500 mg/100 ml for 1 h had no significant (P > 0.05) effect on responses to ACh. Pretreatment with superoxide dismutase, catalase, indomethacin, or meclofenamic acid preserved EDRF-mediated vasodilation during exposure to a D-glucose concentration of 500 mg/100 ml at almost all the ACh dosages tested. These results indicate that oxygen radicals formed in part by increased eicosanoid synthesis during exposure to D-glucose hyperglycemia interfere with the EDRF mechanism before its action on the microvascular smooth muscle.
This article has been cited by other articles:
|
|
 |
|
  S. Chu and H. G. Bohlen High concentration of glucose inhibits glomerular endothelial eNOS through a PKC mechanism Am J Physiol Renal Physiol, September 1, 2004; 287(3): F384 - F392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Bagi, E. Toth, A. Koller, and G. Kaley Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH4 Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H626 - H633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Bohlen Protein kinase {beta}II in Zucker obese rats compromises oxygen and flow-mediated regulation of nitric oxide formation Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H492 - H497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Bohlen and G. P. Nase Obesity lowers hyperglycemic threshold for impaired in vivo endothelial nitric oxide function Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H391 - H397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Kersten, W. G. Toller, J. P. Tessmer, P. S. Pagel, and D. C. Warltier Hyperglycemia reduces coronary collateral blood flow through a nitric oxide-mediated mechanism Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2097 - H2104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Booth, T. J. Stalker, A. M. Lefer, and R. Scalia Elevated ambient glucose induces acute inflammatory events in the microvasculature: effects of insulin Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E848 - E856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Beckman, A. B. Goldfine, M. B. Gordon, and M. A. Creager Ascorbate Restores Endothelium-Dependent Vasodilation Impaired by Acute Hyperglycemia in Humans Circulation, March 27, 2001; 103(12): 1618 - 1623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Brodsky, A. M. Morrishow, N. Dharia, S. S. Gross, and M. S. Goligorsky Glucose scavenging of nitric oxide Am J Physiol Renal Physiol, March 1, 2001; 280(3): F480 - F486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Bohlen and G. P. Nase Arteriolar nitric oxide concentration is decreased during hyperglycemia-induced {beta}II PKC activation Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H621 - H627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Goligorsky, J. Chen, and S. Brodsky Workshop: Endothelial Cell Dysfunction Leading to Diabetic Nephropathy : Focus on Nitric Oxide Hypertension, February 1, 2001; 37(2): 744 - 748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mori, G. L. King, A. C. Clermont, D. K. Bursell, and S.-E. Bursell Endothelin-3 Regulation of Retinal Hemodynamics in Nondiabetic and Diabetic Rats Invest. Ophthalmol. Vis. Sci., November 1, 2000; 41(12): 3955 - 3962. [Abstract] [Full Text]
|
|
|
|
|
|
H. G. Bohlen and G. P. Nase Dependence of intestinal arteriolar regulation on flow-mediated nitric oxide formation Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2249 - H2258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Lenda, B. A. Sauls, and M. A. Boegehold Reactive oxygen species may contribute to reduced endothelium-dependent dilation in rats fed high salt Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H7 - H14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Ogonowski, W. H. Kaesemeyer, L. Jin, V. Ganapathy, F. H. Leibach, and R. W. Caldwell Effects of NO donors and synthase agonists on endothelial cell uptake of L-Arg and superoxide production Am J Physiol Cell Physiol, January 1, 2000; 278(1): C136 - C143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Gutterman Adventitia-dependent influences on vascular function Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1265 - H1272. [Full Text] [PDF]
|
|
|
|
|
|
J. M. Lash, G. P. Nase, and H. G. Bohlen Acute hyperglycemia depresses arteriolar NO formation in skeletal muscle Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1513 - H1520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Brands and S. M. Fitzgerald Acute Endothelium-Mediated Vasodilation Is Not Impaired at the Onset of Diabetes Hypertension, September 1, 1998; 32(3): 541 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Bohlen Mechanism of increased vessel wall nitric oxide concentrations during intestinal absorption Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H542 - H550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Kersten, T. J. Schmeling, K. G. Orth, P. S. Pagel, and D. C. Warltier Acute hyperglycemia abolishes ischemic preconditioning in vivo Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H721 - H725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Williams, A. B. Goldfine, F. K. Timimi, H. H. Ting, M.-A. Roddy, D. C. Simonson, and M. A. Creager Acute Hyperglycemia Attenuates Endothelium-Dependent Vasodilation in Humans In Vivo Circulation, May 5, 1998; 97(17): 1695 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Pieper Review of Alterations in Endothelial Nitric Oxide Production in Diabetes : Protective Role of Arginine on Endothelial Dysfunction Hypertension, May 1, 1998; 31(5): 1047 - 1060. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kimura, M. Oike, and Y. Ito Acute Glucose Overload Abolishes Ca2+ Oscillation in Cultured Endothelial Cells From Bovine Aorta : A Possible Role of Superoxide Anion Circ. Res., April 6, 1998; 82(6): 677 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. P. Nase and M. A. Boegehold Postjunctional alpha 2-adrenoceptors are not present in proximal arterioles of rat intestine Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H202 - H208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Giugliano, R. Marfella, L. Coppola, G. Verrazzo, R. Acampora, R. Giunta, F. Nappo, C. Lucarelli, and F. D'Onofrio Vascular Effects of Acute Hyperglycemia in Humans Are Reversed by L-Arginine : Evidence for Reduced Availability of Nitric Oxide During Hyperglycemia Circulation, April 1, 1997; 95(7): 1783 - 1790. [Abstract] [Full Text]
|
|
|
|
|
|
H. O. Steinberg and A. D. Baron Insulin-Dependent Diabetes Mellitus and Nitrovasodilation: Important and Complex Interactions Circulation, February 4, 1997; 95(3): 560 - 561. [Full Text]
|
|
|
|
|
|
S. Makimattila, M. Mantysaari, P.-H. Groop, P. Summanen, A. Virkamaki, A. Schlenzka, J. Fagerudd, and H. Yki-Jarvinen Hyperreactivity to Nitrovasodilators in Forearm Vasculature Is Related to Autonomic Dysfunction in Insulin-Dependent Diabetes Mellitus Circulation, February 4, 1997; 95(3): 618 - 625. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. J. Cipolla, J. M. Porter, G. Osol, and W. G. Mayhan High Glucose Concentrations Dilate Cerebral Arteries and Diminish Myogenic Tone Through an Endothelial Mechanism Stroke, February 1, 1997; 28(2): 405 - 411. [Abstract] [Full Text]
|
|
|
|
|
|
J. Angulo, C. F. Sanchez-Ferrer, C. Peiro, J. Marin, and L. Rodriguez-Manas Impairment of Endothelium-Dependent Relaxation by Increasing Percentages of Glycosylated Human Hemoglobin: Possible Mechanisms Involved Hypertension, October 1, 1996; 28(4): 583 - 592. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Beckman, A. B. Goldfine, M. B. Gordon, L. A. Garrett, and M. A. Creager Inhibition of Protein Kinase C{beta} Prevents Impaired Endothelium-Dependent Vasodilation Caused by Hyperglycemia in Humans Circ. Res., January 11, 2002; 90(1): 107 - 111. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
