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Am J Physiol Heart Circ Physiol 265: H47-H51, 1993;
0363-6135/93 $5.00
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AJP - Heart and Circulatory Physiology, Vol 265, Issue 1 47-H51, Copyright © 1993 by American Physiological Society

ARTICLES

Endothelium-derived nitric oxide reduces baseline venous tone in awake instrumented rats

M. R. Glick, J. D. Gehman and J. A. Gascho
Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

To determine whether nitric oxide, which is likely endothelium-derived relaxing factor (EDRF), modulates baseline venous tone, the effects of intravenous NG-monomethyl-L-arginine (L-NMMA) (3-25 mg/kg), an EDRF inhibitor, on mean circulatory filling pressure (MCFP) were determined in 10 awake instrumented rats. MCFP, the equilibrated systemic pressure occurring when the circulation is arrested by transient inflation of a balloon in the right atrium, is a measure of total venous capacitance. L-NMMA caused a dose-dependent increase in mean arterial pressure and a dose-dependent decrease in heart rate. MCFP rose from 6.6 +/- 0.2 to 7.6 +/- 0.2 mmHg at the highest L-NMMA dose. The effects of L-NMMA on MCFP were reversed with L-arginine. In an additional four rats, in which hexamethonium was administered to induce ganglionic blockade, L-NMMA (25 mg/kg) caused a similar increase in MCFP (4.1 +/- 0.6 to 5.0 +/- 0.7 mmHg, P = 0.22) during the ganglionic blocked state as during the control unblocked state. These findings suggest that nitric oxide, which is likely EDRF, reduces baseline venous tone.


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