| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 265, Issue 2 543-H552, Copyright © 1993 by American Physiological Society
ARTICLES |
Y. Yuan, W. M. Chilian, H. J. Granger and D. C. Zawieja
Microcirculation Research Institute, Texas A & M University Health Science Center, College Station 77843-1114.
This study reports measurements of albumin permeability in isolated coronary venules. The isolated microvessel technique allows the quantification of transmural exchange of macromolecules under tightly controlled physical and chemical conditions. Transvenular exchange of albumin was studied in isolated coronary venules during alterations in filtration rate caused by changes in intravascular pressure. The apparent permeability coefficient of albumin (Pa) at an intraluminal pressure of 11 cmH2O was 3.92 +/- 0.43 x 10(-6) cm/s. Elevating intraluminal pressure to 16 and 21 cmH2O increased Pa to 5.13 +/- 0.57 x 10(-6) and 6.78 +/- 0.66 x 10(-6) cm/s, respectively. Calculation of the true diffusive permeability coefficient of albumin (Pd) at zero filtration rate was 1.54 x 10(-6) cm/s. The product of hydraulic conductance (Lp) and (1 - sigma), where sigma is the solute reflection coefficient, was 3.25 x 10(-7) cm.s-1 x cmH2O-1. At a net filtration pressure of 4-5 cmH2O, diffusion accounts for > 60% of total albumin transport across the venular wall. Transmural albumin flux is very sensitive to filtration rate, rising 6.7% for each cmH2O elevation of net filtration pressure. At 11 cmH2O net filtration pressure, convection accounts for nearly 70% of net albumin extravasation from the venular lumen. We suggest that the isolated coronary venule is a suitable preparation for the study of solute exchange in the heart.
This article has been cited by other articles:
|
|
 |
|
  J. W. Breslin, H. Sun, W. Xu, C. Rodarte, A. B. Moy, M. H. Wu, and S. Y. Yuan Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H741 - H750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ono, R. Mizuno, and T. Ohhashi Effective permeability of hydrophilic substances through walls of lymph vessels: roles of endothelial barrier Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1676 - H1682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. H. Huxley, J. Wang, and S. P. Whitt Sexual dimorphism in the permeability response of coronary microvessels to adenosine Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H2006 - H2013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Tinsley, E. E. Ustinova, W. Xu, and S. Y. Yuan Src-dependent, neutrophil-mediated vascular hyperpermeability and beta -catenin modification Am J Physiol Cell Physiol, December 1, 2002; 283(6): C1745 - C1751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Yuan, E. E. Ustinova, M. H. Wu, J. H. Tinsley, W. Xu, F. L. Korompai, and A. C. Taulman Protein Kinase C Activation Contributes to Microvascular Barrier Dysfunction in the Heart at Early Stages of Diabetes Circ. Res., September 1, 2000; 87(5): 412 - 417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. H. Huxley and D. A. Williams Role of a glycocalyx on coronary arteriole permeability to proteins: evidence from enzyme treatments Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1177 - H1185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Michel and F. E. Curry Microvascular Permeability Physiol Rev, July 1, 1999; 79(3): 703 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. m. Wu, Y. Yuan, D. C. Zawieja, J. Tinsley, and H. J. Granger Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H535 - H542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Granger Cardiovascular physiology in the twentieth century: great strides and missed opportunities Am J Physiol Heart Circ Physiol, December 1, 1998; 275(6): H1925 - H1936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Huang, M. Wu, C. Meininger, K. Kelly, and Y. Yuan Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1138 - H1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Huang and Y. Yuan Interaction of PKC and NOS in signal transduction of microvascular hyperpermeability Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2442 - H2451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Chilian Coronary Microcirculation in Health and Disease: Summary of an NHLBI Workshop Circulation, January 21, 1997; 95(2): 522 - 528. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
