| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 265, Issue 6 2175-H2183, Copyright © 1993 by American Physiological Society
ARTICLES |
A. G. Durmowicz, E. C. Orton and K. R. Stenmark
Cardiovascular-Pulmonary Research Laboratory, Colorado Health Sciences Center, Denver.
Severe neonatal pulmonary hypertension (PH) may have both reversible (vasoconstrictive) and "fixed" (vasodilator unresponsive) components. To assess when and to what degree vasodilator unresponsive PH developed in the neonate, pulmonary arterial pressures (PAP) and cardiac outputs (CO) were measured, and total pulmonary resistances (TPR) were calculated in neonatal calves exposed to chronic hypoxia (CH) (barometric pressure of 430 mmHg = 4,570 m) for 1, 3, 7, and 14 days under both normoxic (barometric pressure of 640 mmHg = 1,500 m) and hypoxic conditions with and without an infusion of the vasodilator acetylcholine (ACh). Studies were done at 4 h and at 2, 4, 8, and 15 days of life in both control and CH animals. The fixed component of PH was defined as that PAP or TPR above the control baseline value which remained in CH animals after an infusion ACh at 1,500 m. Small pulmonary arteries were also examined histologically in an attempt to correlate relative changes in the reversible and fixed elements of PH with alterations in vessel structure. Chronic exposure to 4,570 m altitude prevented the normal postnatal fall in PAP and TPR observed in control animals. Instead, PAP, TPR, and the structure of small pulmonary arteries initially remained similar to those of the 4-h-old newborn. By 7 days exposure to 4,570 m, a significant element of fixed PH developed, which increased dramatically between the 7- and 14-day exposure periods and appeared to correlate with a narrowed pulmonary artery lumen and increased medial and adventitial thickness.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  D. K. Hirenallur-S., S. T. Haworth, J. T. Leming, J. Chang, G. Hernandez, J. B. Gordon, and N. J. Rusch Upregulation of vascular calcium channels in neonatal piglets with hypoxia-induced pulmonary hypertension Am J Physiol Lung Cell Mol Physiol, November 1, 2008; 295(5): L915 - L924. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Lammers, P. H. Kao, H. J. Qi, K. Hunter, C. Lanning, J. Albietz, S. Hofmeister, R. Mecham, K. R. Stenmark, and R. Shandas Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1451 - H1459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Crossno Jr., C. V. Garat, J. E. B. Reusch, K. G. Morris, E. C. Dempsey, I. F. McMurtry, K. R. Stenmark, and D. J. Klemm Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L885 - L897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Stenmark, N. Davie, M. Frid, E. Gerasimovskaya, and M. Das Role of the Adventitia in Pulmonary Vascular Remodeling Physiology, April 1, 2006; 21(2): 134 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Raj and L. Shimoda Oxygen-dependent signaling in pulmonary vascular smooth muscle Am J Physiol Lung Cell Mol Physiol, October 1, 2002; 283(4): L671 - L677. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Karamsetty, J. R. Klinger, and N. S. Hill Phytoestrogens Restore Nitric Oxide-Mediated Relaxation in Isolated Pulmonary Arteries from Chronically Hypoxic Rats J. Pharmacol. Exp. Ther., June 1, 2001; 297(3): 968 - 974. [Abstract] [Full Text]
|
|
|
|
|
|
M. S. Lemler, R. D. Bies, M. G. Frid, A. Sastravaha, L. S. Zisman, T. Bohlmeyer, A. M. Gerdes, J. T. Reeves, and K. R. Stenmark Myocyte cytoskeletal disorganization and right heart failure in hypoxia-induced neonatal pulmonary hypertension Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H1365 - H1376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Berkenbosch, J. Baribeau, and T. Perreault Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension Am J Physiol Lung Cell Mol Physiol, February 1, 2000; 278(2): L276 - L283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Durmowicz and K. R. Stenmark Mechanisms of Structural Remodeling in Chronic Pulmonary Hypertension Pediatr. Rev., November 1, 1999; 20(11): e91 - e102. [Full Text] [PDF]
|
|
|
|
|
|
L. Stiebellehner, J. K. Belknap, B. Ensley, A. Tucker, E. C. Orton, J. T. Reeves, and K. R. Stenmark Lung endothelial cell proliferation in normal and pulmonary hypertensive neonatal calves Am J Physiol Lung Cell Mol Physiol, September 1, 1998; 275(3): L593 - L600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Carver Jr., S. K. Srinathan, C. R. Velloff, and J. Julio Pérez Fontán Increased Type I Procollagen mRNA in Airways and Pulmonary Vessels after Vagal Denervation in Rats Am. J. Respir. Cell Mol. Biol., December 1, 1997; 17(6): 691 - 701. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
