AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 266: H531-H539, 1994;
0363-6135/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bosso, F. J.
Right arrow Articles by Pilati, C. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bosso, F. J.
Right arrow Articles by Pilati, C. F.

AJP - Heart and Circulatory Physiology, Vol 266, Issue 2 531-H539, Copyright © 1994 by American Physiological Society

ARTICLES

Myocardial work load is a major determinant of norepinephrine-induced left ventricular dysfunction

F. J. Bosso, F. D. Allman and C. F. Pilati
Department of Physiology, Northeastern Ohio Universities College of Medicine, Rootstown 44272.

This study was conducted to determine whether increased myocardial energy demand plays a role in norepinephrine (NE)-induced left ventricular (LV) dysfunction. A range of arterial pressure-heart rate (P-R) products (myocardial energy demand) was produced in both conscious and pentobarbital sodium-anesthetized rabbits with the same dose of NE (10 micrograms priming bolus plus 2.5 micrograms.kg-1 x min-1 for 2.5 h). After NE treatment, LV function was evaluated in vitro and found to be markedly diminished in the rabbits that had an elevated P-R product. In contrast, LV function was not significantly affected when the P-R product was maintained near control levels during NE treatment. In separate experiments, rabbit hearts were isolated and exposed to NE (10,000 or 50,000 pg/ml) for 2.5 h under low P-R product conditions. These hearts exhibited a dose-dependent decrease in LV function that was modest compared with that observed in rabbits that had elevated P-R products during in vivo NE treatment. Our results suggest that high concentrations of NE may cause modest degrees of LV dysfunction independently of increases in myocardial energy demand, but the LV dysfunction is exacerbated when myocardial energy demand is elevated.


This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
R. V. Venkateswaran, V. B. Patchell, I. C. Wilson, J. G. Mascaro, R. D. Thompson, D. W. Quinn, R. A. Stockley, J. H. Coote, and R. S. Bonser
Early Donor Management Increases the Retrieval Rate of Lungs for Transplantation
Ann. Thorac. Surg., January 1, 2008; 85(1): 278 - 286.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
J. M. Smith and C. F. Pilati
Effect of Massive Sympathetic Nervous System Activation on Coronary Blood Flow and Myocardial Energy Pool
Experimental Biology and Medicine, February 1, 2002; 227(2): 125 - 132.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online