AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 266: H1348-H1356, 1994;
0363-6135/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Niimi, Y.
Right arrow Articles by Hirakawa, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Niimi, Y.
Right arrow Articles by Hirakawa, K.

AJP - Heart and Circulatory Physiology, Vol 266, Issue 4 1348-H1356, Copyright © 1994 by American Physiological Society

ARTICLES

Repeated endothelial removal augments intimal thickening and attenuates EDRF release

Y. Niimi, H. Azuma and K. Hirakawa
Department of Neurosurgery, Tokyo Medical and Dental University, Japan.

To evaluate the significance of repeated denudation injury in progression of atherosclerosis, we performed a single and then a second balloon denudation on the rabbit carotid arteries. Morphological examinations and organ chamber experiments were performed, and the results were compared. On morphological examinations, reendothelialization was almost completed in 2 wk after redenudation, whereas it required 6 wk after a single denudation. Intimal thickening progressed after redenudation. Organ chamber experiments showed that contractile responses and endothelium-independent relaxation remained unchanged after redenudation. Endothelium-dependent relaxations to acetylcholine, ADP, and substance P decreased progressively by repeating denudation. These relaxation responses were inhibited by NG-nitro-L-arginine, hemoglobin, and methylene blue and were considered to be associated with the production and/or release of endothelium-derived relaxing factor-nitric oxide (EDRF-NO). The diffusion barrier mechanism for the decreased endothelium-dependent relaxations was ruled out using sandwich experiments. In conclusion, repeated endothelial denudation caused progression of intimal thickening and acceleration of endothelial regeneration, and repeated endothelial regeneration resulted in progressively less production and/or release of EDRF-NO.


This article has been cited by other articles:


Home page
 CirculationHome page
A. MaassenVanDenBrink, M. Reekers, W. A. Bax, M. D. Ferrari, and P. R. Saxena
Coronary Side-Effect Potential of Current and Prospective Antimigraine Drugs
Circulation, July 7, 1998; 98(1): 25 - 30.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J.-i. Abe, J.-o Deguchi, T. Matsumoto, N. Takuwa, M. Noda, M. Ohno, M. Makuuchi, K. Kurokawa, and Y. Takuwa
Stimulated Activation of Platelet-Derived Growth Factor Receptor In Vivo in Balloon-Injured Arteries : A Link Between Angiotensin II and Intimal Thickening
Circulation, September 16, 1997; 96(6): 1906 - 1913.
[Abstract] [Full Text]

Home page
 StrokeHome page
M. Aoyagi, M. Yamamoto, H. Wakimoto, H. Azuma, K. Hirakawa, and K. Yamamoto
Immunohistochemical Detection of Ki-67 in Replicative Smooth Muscle Cells of Rabbit Carotid Arteries After Balloon Denudation
Stroke, December 1, 1995; 26(12): 2328 - 2332.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
S. M. Schwartz, D. deBlois, and E. R. M. O'Brien
The Intima : Soil for Atherosclerosis and Restenosis
Circ. Res., September 1, 1995; 77(3): 445 - 465.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online